气候变化领域集成服务门户(CCPortal): Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features

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DOI	10.1016/j.scib.2020.03.040
	Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features
	Lv X.; He C.; Huang C.; Hua G.; Chen X.; Timm B.K.; Maclin V.M.; Haggerty A.A.; Aust S.K.; Golden D.M.; Dave B.J.; Tseng Y.-A.; Chen L.; Wang H.; Chen P.; Klinkebiel D.L.; Karpf A.R.; Dong J.; Drapkin R.I.; Rueda B.R.; Davis J.S.; Wang C.
发表日期	2020
ISSN	20959273
起始页码	1281
结束页码	1296
卷号	65 期号:15
英文摘要	Understanding the cell-of-origin of ovarian high grade serous cancer (HGSC) is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological cancer. Recently, a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS studies. The cell-of-origin of this subtype of ovarian cancer is unknown. While pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology, we unexpectedly found that the Yes-associated protein 1 (YAP1), the major effector of the Hippo signaling pathway, induced dedifferentiation and reprogramming of the ovarian granulosa cells, a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity, leading to the development of high grade ovarian cancer with serous features. Our research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features. © 2020 Science China Press
关键词	Cell dedifferentiation Cell reprogramming Mesenchymal type of high grade serous cancer Ovarian granulosa cells The Hippo pathway YAP1 oncogene
英文关键词	Cell signaling; Cells; Diagnosis; Diseases; Physiology; Early diagnosis; Granulosa cells; High grades; High plasticity; Ovarian cancers; Research results; Signaling pathways; Cytology
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207144
作者单位	Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, United States; College of Animal Sciences and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 47000, China; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, United States; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States; Heartland Center for Reproductive Medicine, Omaha, NE 68198, United States; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, United States; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; College of Life and Environmental Science, Wenzhou University, We...
推荐引用方式 GB/T 7714	Lv X.,He C.,Huang C.,et al. Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features[J],2020,65(15).
APA	Lv X..,He C..,Huang C..,Hua G..,Chen X..,...&Wang C..(2020).Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.Science Bulletin,65(15).
MLA	Lv X.,et al."Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features".Science Bulletin 65.15(2020).