气候变化领域集成服务门户(CCPortal): Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones

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DOI	10.1016/j.scib.2019.12.023
	Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones
	Luo J.; Chen G.-S.; Chen S.-J.; Liu Y.-L.
发表日期	2020
ISSN	20959273
起始页码	670
结束页码	677
卷号	65 期号:8
英文摘要	An expedient and economic approach for constructing O,O,N-spiro compounds consisting of both a 1,3-oxazine and a furan ring through a catalyst-free formal [4+1]/[4+2] cycloaddition cascade sequence of isocyanides with two molecules of acylketene formed in situ through thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones was developed. The reaction displayed good functional group tolerance and was compatible with different isocyanides and 2-diazo-1,3-diketones. Furthermore, preliminary asymmetric attempts of this reaction are made by utilizing optically pure isocyanides as inputs, and moderate diastereomeric induction was observed. © 2019 Science China Press
关键词	2-Diazo-1,3-diketone Acylketene Catalyst-free Isocyanide Wolff rearrangement
英文关键词	Catalysts; Molecules; 2-Diazo-1,3-diketone; Acylketene; Catalyst-free; Isocyanides; Wolff rearrangement; Cyanides
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207141
作者单位	School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, China
推荐引用方式 GB/T 7714	Luo J.,Chen G.-S.,Chen S.-J.,et al. Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones[J],2020,65(8).
APA	Luo J.,Chen G.-S.,Chen S.-J.,&Liu Y.-L..(2020).Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones.Science Bulletin,65(8).
MLA	Luo J.,et al."Catalyst-free formal [4+1]/[4+2] cyclization cascade sequence of isocyanides with two molecules of acylketene formed in situ from thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones".Science Bulletin 65.8(2020).