气候变化领域集成服务门户(CCPortal): SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT

CCPortal

DOI	10.1016/j.scib.2020.01.013
	SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT
	Jiang Z.; Lu L.; Liu Y.; Zhang S.; Li S.; Wang G.; Wang P.; Chen L.
发表日期	2020
ISSN	20959273
起始页码	842
结束页码	853
卷号	65 期号:10
英文摘要	Epithelial–mesenchymal transition (EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration, and cancer metastasis. A hallmark of EMT is the switch-like behavior during state transition, which is characteristic of phase transitions. Hence, detecting the tipping point just before mesenchymal state transition is critical for understanding molecular mechanism of EMT. Through dynamic network biomarkers (DNB) model, a DNB group with 37 genes was identified which can provide the early-warning signals of EMT. Particularly, we found that two DNB genes, i.e., SMAD7 and SERPINE1 promoted EMT by switching their regulatory network which was further validated by biological experiments. Survival analyses revealed that SMAD7 and SERPINE1 as DNB genes further acted as prognostic biomarkers for lung adenocarcinoma. © 2020 Science China Press
关键词	Bistability Dynamic network biomarker Epithelial–mesenchymal transition Quantitative real-time PCR Tipping point
英文关键词	Diseases; Genes; Optical bistability; Polymerase chain reaction; Tissue regeneration; Biological experiments; Biological process; Dynamic network; Molecular mechanism; Quantitative real time PCR; Regulatory network; Survival analysis; Tipping point; Biomarkers
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207077
作者单位	Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China; Bio-med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute of Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China; Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Guangdong Provincial Key Laboratory of Cell Microenviroment and Disease Research, Guangdong Provincial Key Laboratory of Computational Science and Material Design, Department of Biology, Southern University of Science ...
推荐引用方式 GB/T 7714	Jiang Z.,Lu L.,Liu Y.,et al. SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT[J],2020,65(10).
APA	Jiang Z..,Lu L..,Liu Y..,Zhang S..,Li S..,...&Chen L..(2020).SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT.Science Bulletin,65(10).
MLA	Jiang Z.,et al."SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT".Science Bulletin 65.10(2020).