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CO2 inhalation enhances the lability of fear memory
项目编号7R01MH113986-03
DU, JIANYANG
项目主持机构UNIVERSITY OF TENNESSEE HEALTH SCI CTR
开始日期2020-05-01
结束日期2023-04-30
英文摘要PROJECT NARRATIVE Uncovering the cellular and molecular mechanisms by which CO2 inhalation mediates the lability of fear memories is very important, especially as it relates to many mental disorders. The outcomes of this project will greatly expand our understanding of memory modification. Moreover, elucidation of this mechanism has the potential to facilitate the development of novel strategies for treating mental illnesses in clinics.
英文关键词Acidosis; Affect; AMPA Receptors; Amygdaloid structure; Animals; Anxiety; ASIC channel; Behavior; Brain; Brain region; Carbon Dioxide; Clinic; conditioned fear; conditioning; Data; Dendritic Spines; Development; Disease; Emotions; Endocytosis; Event; Extinction (Psychology); extracellular; fear memory; Fright; Goals; Inhalation; Knockout Mice; Lead; Mediating; Memory; memory retrieval; Mental disorders; Methods; Modification; Molecular; Mus; neuronal circuitry; neurotransmission; Neurotransmitters; novel strategies; novel therapeutic intervention; novel therapeutics; optogenetics; Outcome; Permeability; Phosphorylation; Play; Post-Traumatic Stress Disorders; postsynaptic; Predisposition; Protons; receptor; Research; Retrieval; Role; Site; Specificity; Synaptic plasticity; Testing; theories; trafficking; Work;
学科分类14 - 医学科学
资助机构US-NIH
项目经费348489
项目类型Non-SBIR/STTR RPGs
国家US
语种英语
文献类型项目
条目标识符http://gcip.llas.ac.cn/handle/2XKMVOVA/191171
推荐引用方式
GB/T 7714		 DU, JIANYANG.CO2 inhalation enhances the lability of fear memory.2020.
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