气候变化领域集成服务门户(CCPortal): In vivo activation of an [FeFe] hydrogenase using synthetic cofactors

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DOI	10.1039/c7ee00135e
	In vivo activation of an [FeFe] hydrogenase using synthetic cofactors
	Khanna N.; Esmieu C.; Mészáros L.S.; Lindblad P.; Berggren G.
发表日期	2017
ISSN	17545692
起始页码	1563
结束页码	1567
卷号	10 期号:7
英文摘要	[FeFe] hydrogenases catalyze the reduction of protons, and oxidation of hydrogen gas, with remarkable efficiency. The reaction occurs at the H-cluster, which contains an organometallic [2Fe] subsite. The unique nature of the [2Fe] subsite makes it dependent on a specific set of maturation enzymes for its biosynthesis and incorporation into the apo-enzyme. Herein we report on how this can be circumvented, and the apo-enzyme activated in vivo by synthetic active site analogues taken up by the living cell. © The Royal Society of Chemistry 2017.
英文关键词	Biochemistry; Organometallics; Active site; Apo-enzymes; Cofactors; H-cluster; Living cell; Oxidation of hydrogen; Reduction of protons; [FeFe]hydrogenases; Enzymes; catalysis; cells and cell components; enzyme; enzyme activity; hydrogen; oxidation; reaction kinetics
语种	英语
来源期刊	Energy & Environmental Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/190455
作者单位	Microbial Chemistry, Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, 75120, Sweden; Molecular Biomimetics, Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, 75120, Sweden
推荐引用方式 GB/T 7714	Khanna N.,Esmieu C.,Mészáros L.S.,et al. In vivo activation of an [FeFe] hydrogenase using synthetic cofactors[J],2017,10(7).
APA	Khanna N.,Esmieu C.,Mészáros L.S.,Lindblad P.,&Berggren G..(2017).In vivo activation of an [FeFe] hydrogenase using synthetic cofactors.Energy & Environmental Science,10(7).
MLA	Khanna N.,et al."In vivo activation of an [FeFe] hydrogenase using synthetic cofactors".Energy & Environmental Science 10.7(2017).