气候变化领域集成服务门户(CCPortal): Prioritized experience replays on a hippocampal predictive map for learning

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DOI	10.1073/pnas.2011266118
	Prioritized experience replays on a hippocampal predictive map for learning
	Igata H.; Ikegaya Y.; Sasaki T.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Hippocampal cells are central to spatial and predictive representations, and experience replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal replay patterns dynamically change during the learning process remains to be elucidated. Here, we designed a spatial task in which rats learned a new behavioral trajectory for reward. We found that as rats updated their behavioral strategies for a novel salient location, hippocampal cell ensembles increased theta-sequences and sharp wave ripple-associated synchronous spikes that preferentially replayed salient locations and reward-related contexts in reverse order. The directionality and contents of the replays progressively varied with learning, including an optimized path that had never been exploited by the animals, suggesting prioritized replays of significant experiences on a predictive map. Online feedback blockade of sharp wave ripples during a learning process inhibited stabilizing optimized behavior. These results implicate learning-associated experience replays that act to learn and reinforce specific behavioral strategies. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Hippocampus; Learning; Place cell; Replay; Ripple
语种	英语
scopus关键词	animal cell; animal experiment; article; hippocampus; human; learning; male; nonhuman; place cell; rat; reward; spike
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181162
作者单位	Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka, 565-0871, Japan; Institute for AI and Beyond, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Kawaguchi, 332-0012, Japan
推荐引用方式 GB/T 7714	Igata H.,Ikegaya Y.,Sasaki T.. Prioritized experience replays on a hippocampal predictive map for learning[J],2021,118(1).
APA	Igata H.,Ikegaya Y.,&Sasaki T..(2021).Prioritized experience replays on a hippocampal predictive map for learning.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Igata H.,et al."Prioritized experience replays on a hippocampal predictive map for learning".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).