气候变化领域集成服务门户(CCPortal): Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain

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DOI	10.1073/pnas.2013232118
	Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain
	Chen Y.; Lin Q.; Liao X.; Zhou C.; He Y.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Aerobic glycolysis (AG), that is, the nonoxidative metabolism of glucose, contributes significantly to anabolic pathways, rapid energy generation, task-induced activity, and neuroprotection; yet high AG is also associated with pathological hallmarks such as amyloid-β deposition. An important yet unresolved question is whether and how the metabolic benefits and risks of brain AG is structurally shaped by connectome wiring. Using positron emission tomography and magnetic resonance imaging techniques as well as computational models, we investigate the relationship between brain AG and the macroscopic connectome. Specifically, we propose a weighted regional distance-dependent model to estimate the total axonal projection length of a brain node. This model has been validated in a macaque connectome derived from tract-tracing data and shows a high correspondence between experimental and estimated axonal lengths. When applying this model to the human connectome, we find significant associations between the estimated total axonal projection length and AG across brain nodes, with higher levels primarily located in the default- mode and prefrontal regions. Moreover, brain AG significantly mediates the relationship between the structural and functional connectomes. Using a wiring optimization model, we find that the estimated total axonal projection length in these high-AG regions exhibits a high extent of wiring optimization. If these high- AG regions are randomly rewired, their total axonal length and vulnerability risk would substantially increase. Together, our results suggest that high-AG regions have expensive but still optimized wiring cost to fulfill metabolic requirements and simultaneously reduce vulnerability risk, thus revealing a benefit-risk balancing mechanism in the human brain. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Computational models; Connectomics; Default mode; Metabolism; Neuroimaging
语种	英语
scopus关键词	aerobic glycolysis; animal experiment; animal model; article; axon; computer model; connectome; controlled study; human; Macaca; neuroimaging; nonhuman; nuclear magnetic resonance imaging; positron emission tomography; prefrontal cortex; structure activity relation; writing
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181144
作者单位	State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, 100875, China; International Data Group (IDG), McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China; School of Systems Science, Beijing Normal University, Beijing, 100875, China; Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Centre for Nonlinear Studies, Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Hong Kong), Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Research Centre, Institute of Research and Continuing Education, Hong Kong Baptist University, Shenzhen, 518000, China; Beijing Computational Science Research Center, Beijing, 100084, China...
推荐引用方式 GB/T 7714	Chen Y.,Lin Q.,Liao X.,et al. Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain[J],2021,118(1).
APA	Chen Y.,Lin Q.,Liao X.,Zhou C.,&He Y..(2021).Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Chen Y.,et al."Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).