气候变化领域集成服务门户(CCPortal): Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

CCPortal

DOI	10.1073/PNAS.2018457118
	Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
	Ostkamp P.; Salmen A.; Pignolet B.; Görlich D.; Andlauer T.F.M.; Schulte-Mecklenbeck A.; Gonzalez-Escamilla G.; Bucciarelli F.; Gennero I.; Breuer J.; Antony G.; Schneider-Hohendorf T.; Mykicki N.; Bayas A.; Bergh F.T.; Bittner S.; Hartung H.-P.; Friese M.A.; Linker R.A.; Luessi F.; Lehmann-Horn K.; Mühlau M.; Paul F.; Stangel M.; Tackenberg B.; Tumani H.; Warnke C.; Weber F.; Wildemann B.; Zettl U.K.; Ziemann U.; Müller-Myhsok B.; Kümpfel T.; Klotz L.; Meuth S.G.; Zipp F.; Hemmer B.; Hohlfeld R.; Brassat D.; Gold R.; Gross C.C.; Lukas C.; Groppa S.; Loser K.; Wiendl H.; Schwab N.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (nNationMS = 946, nBIONAT = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-β–treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Latitude; Melanocortin 1 receptor; Multiple sclerosis; Sunlight; Vitamin D
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181125
作者单位	Department of Neurology, Institute of Translational Neurology, University of Muenster, Muenster, 48149, Germany; Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, 44801, Germany; Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, 3012, Switzerland; Neurosciences Department, Centres de Ressources et de Compétences-Sclérose en Plaques, Centre Hospitalier Univeresitaire Toulouse, Toulouse, 31300, France; Center for Physiopathology of Toulouse Purpan, INSERM U1043, CNRS U5282, Université Toulouse III, Toulouse, 31330, France; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, 48149, Germany; Max Planck Institute of Psychiatry, Munich, 80804, Germany; Department of Neurology, School of Medicine, Technical University of Munich, Munich, 80333, Germany; Department of Neurology, Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, 55131, Germany; ...
推荐引用方式 GB/T 7714	Ostkamp P.,Salmen A.,Pignolet B.,et al. Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity[J],2021,118(1).
APA	Ostkamp P..,Salmen A..,Pignolet B..,Görlich D..,Andlauer T.F.M..,...&Schwab N..(2021).Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Ostkamp P.,et al."Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).