气候变化领域集成服务门户(CCPortal): Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response

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DOI	10.1073/PNAS.2011709118
	Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response
	Marsland R.; III; Howell O.; Mayer A.; Mehta P.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Regulatory T cells (Tregs) play a crucial role in mediating immune response. Yet an algorithmic understanding of the role of Tregs in adaptive immunity remains lacking. Here, we present a biophysically realistic model of Treg-mediated self-tolerance in which Tregs bind to self-antigens and locally inhibit the proliferation of nearby activated T cells. By exploiting a duality between ecological dynamics and constrained optimization, we show that Tregs tile the potential antigen space while simultaneously minimizing the overlap between Treg activation profiles. We find that for sufficiently high Treg diversity, Treg-mediated self-tolerance is robust to fluctuations in self-antigen concentrations but lowering the Treg diversity results in a sharp transition—related to the Gardner transition in perceptrons—to a regime where changes in self-antigen concentrations can result in an autoimmune response. We propose an experimental test of this transition in immune-deficient mice and discuss potential implications for autoimmune diseases. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Adaptive immunity; Biophysics; Ecology; Optimization; Tregs
语种	英语
scopus关键词	algorithm; antigen binding; Article; autoimmune disease; bioaccumulation; biodiversity; biophysics; cell interaction; ecosystem; human; human cell; immune response; lymphocyte activation; lymphocyte function; lymphocyte proliferation; mathematical computing; priority journal; process optimization; regulatory T lymphocyte
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181124
作者单位	Department of Physics, Boston University, Boston, MA 02215, United States; Lewis-Sigler Institute, Princeton University, Princeton, NJ 08540, United States; Faculty of Computing and Data Science, Boston University, Boston, MA 02215, United States
推荐引用方式 GB/T 7714	Marsland R.,III,Howell O.,et al. Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response[J],2021,118(1).
APA	Marsland R.,III,Howell O.,Mayer A.,&Mehta P..(2021).Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Marsland R.,et al."Tregs self-organize into a computing ecosystem and implement a sophisticated optimization algorithm for mediating immune response".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).