气候变化领域集成服务门户(CCPortal): Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis

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DOI	10.1073/PNAS.2013686117
	Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis
	Wang M.; Yang Y.; Cansever D.; Wang Y.; Kantores C.; Messiaen S.; Moison D.; Livera G.; Chakarov S.; Weinberger T.; Stremmel C.; Fijak M.; Klein B.; Pleuger C.; Lian Z.; Ma W.; Liu Q.; Klee K.; Händler K.; Ulas T.; Schlitzer A.; Schultze J.L.; Becher B.; Greter M.; Liu Z.; Ginhoux F.; Epelman S.; Schulz C.; Meinhardt A.; Bhushan S.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	Macrophages are the principal immune cells of the epididymis and testis, but their origins, heterogeneity, development, and maintenance are not well understood. Here, we describe distinct populations of epididymal and testicular macrophages that display an organ-specific cellular identity. Combining in vivo fate-mapping, chimeric and parabiotic mouse models with in-depth cellular analyses, we found that CD64hiMHCIIlo and CD64loMHCIIhi macrophage populations of epididymis and testis arise sequentially from yolk sac erythro-myeloid progenitors, embryonic hematopoiesis, and nascent neonatal monocytes. While monocytes were the major developmental source of both epididymal and testicular macrophages, both populations self-maintain in the steady-state independent of bone marrow hematopoietic precursors. However, after radiation-induced macrophage ablation or during infection, bone marrow-derived circulating monocytes are recruited to the epididymis and testis, giving rise to inflammatory macrophages that promote tissue damage. These results define the layered ontogeny, maintenance and inflammatory response of macrophage populations in the male reproductive organs. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Epididymis; Macrophgaes; Monocytes; Ontogeny; Testis
语种	英语
scopus关键词	CD64 antigen; colony stimulating factor 1; major histocompatibility antigen class 2; adult; animal experiment; animal model; animal tissue; Article; bacterial infection; bone marrow transplantation; controlled study; epididymis; erythroid precursor cell; hematopoiesis; immunophenotyping; inflammation; macrophage; male; monocyte; mouse; myeloid progenitor cell; nonhuman; parabiosis; priority journal; testis
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181117
作者单位	Medical Research Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, Giessen, 35392, Germany; Institute of Experimental Immunology, University of Zurich, Zurich, 8057, Switzerland; Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l’Energie Atomique/Direction de la Recherche Fondamentale, Institut de Biologie Francois Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses, F-92265, France; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) BIOPOLIS, Singapore, 138648, Singapore; Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, Munich, 81377, G...
推荐引用方式 GB/T 7714	Wang M.,Yang Y.,Cansever D.,et al. Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis[J],2021,118(1).
APA	Wang M..,Yang Y..,Cansever D..,Wang Y..,Kantores C..,...&Bhushan S..(2021).Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Wang M.,et al."Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).