气候变化领域集成服务门户(CCPortal): Discrimination and anxiety: Using multiple polygenic scores to control for genetic liability

CCPortal

DOI	10.1073/PNAS.2017224118
	Discrimination and anxiety: Using multiple polygenic scores to control for genetic liability
	Cuevas A.G.; Mann F.D.; Williams D.R.; Krueger R.F.
发表日期	2021
ISSN	00278424
卷号	118 期号:1
英文摘要	An established body of research indicates that discrimination is associated with increased symptoms of anxiety and negative affect. However, the association cannot be interpreted unambiguously as an exposure effect because a common set of genetic factors can simultaneously contribute to increased liability for symptoms of anxiety, negative affect, and the perception of discrimination. The present study elucidates the association between discrimination and anxiety/negative affect by implementing strict genetic controls in a large sample of adults. We used data from the biomarker project of the Study of Midlife Development in the United States (MIDUS), a national probability sample of noninstitutionalized, English-speaking respondents aged 25 to 74 y. Participants who consented to provide genetic data were biologically unrelated and of European ancestry as determined by genotype principal components analysis (n = 1,146). A single structural regression model was fit to the data with three measures of discrimination specified to load onto a latent factor and six measures of anxiety and negative affect specified to load onto a second latent factor. After accounting for potential genetic confounds—polygenic scores for anxiety, depression, and neuroticism and the first five genetic principal components—greater discrimination was associated with greater anxiety/negative affect (β = 0.53, SE = 0.04, P < 0.001). Findings suggest that measures of perceived discrimination should be considered environmental risk factors for anxiety/negative affect rather than indices of genetic liability for anxiety, depression, or neuroticism. Clinical interventions and prevention measures should focus on ways to mitigate the impact of discrimination to improve mental health at the population level. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Anxiety; Discrimination; Internalizing; Negative affect; Polygenic scores
语种	英语
scopus关键词	adult; aged; anxiety; Article; Caucasian; depression; female; genetic risk score; genetic susceptibility; human; internalization (behavior); male; neurosis; principal component analysis; priority journal; social discrimination; social exclusion; United States
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181115
作者单位	Department of Community Health, Tufts University, Medford, MA 02155, United States; Department of Family, Population, and Preventative Medicine, Program in Public Health, Stony Brook University, Stony Brook, NY 11794, United States; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of African and African American Studies, Harvard University, Cambridge, MA 02138, United States; Department of Psychology, University of Minnesota, Minneapolis, MN 55455, United States
推荐引用方式 GB/T 7714	Cuevas A.G.,Mann F.D.,Williams D.R.,et al. Discrimination and anxiety: Using multiple polygenic scores to control for genetic liability[J],2021,118(1).
APA	Cuevas A.G.,Mann F.D.,Williams D.R.,&Krueger R.F..(2021).Discrimination and anxiety: Using multiple polygenic scores to control for genetic liability.Proceedings of the National Academy of Sciences of the United States of America,118(1).
MLA	Cuevas A.G.,et al."Discrimination and anxiety: Using multiple polygenic scores to control for genetic liability".Proceedings of the National Academy of Sciences of the United States of America 118.1(2021).