气候变化领域集成服务门户(CCPortal): Reston virus causes severe respiratory disease in young domestic pigs

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DOI	10.1073/pnas.2015657118
	Reston virus causes severe respiratory disease in young domestic pigs
	Haddock E.; Saturday G.; Feldmann F.; Hanley P.W.; Okumura A.; Lovaglio J.; Long D.; Thomas T.; Scott D.P.; Pulliam M.; Richt J.A.; de Wit E.; Feldmann H.
发表日期	2021
ISSN	00278424
卷号	118 期号:2
英文摘要	Reston virus (RESTV), an ebolavirus, causes clinical disease in macaques but has yet only been associated with rare asymptomatic infections in humans. Its 2008 emergence in pigs in the Philippines raised concerns about food safety, pathogenicity, and zoonotic potential, questions that are still unanswered. Until today, the virulence of RESTV for pigs has remained elusive, with unclear pathogenicity in naturally infected animals and only one experimental study demonstrating susceptibility and evidence for shedding but no disease. Here we show that combined oropharyngeal and nasal infection of young (3- to 7-wk-old) Yorkshire cross pigs with RESTV resulted in severe respiratory disease, with most animals reaching humane endpoint within a week. RESTV-infected pigs developed severe cyanosis, tachypnea, and acute interstitial pneumonia, with RESTV shedding from oronasal mucosal membranes. Our studies indicate that RESTV should be considered a livestock pathogen with zoonotic potential. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Infection; Pig; Reston virus; RESTV; Severe respiratory disease
语种	英语
scopus关键词	age; animal experiment; animal model; animal tissue; Article; controlled study; cyanosis; disease severity; domestic pig; Ebola hemorrhagic fever; female; interstitial pneumonia; lung alveolus cell type 2; lung alveolus macrophage; male; nonhuman; priority journal; Reston virus infection; tachypnea; viral respiratory tract infection; virus shedding; virus virulence; Yorkshire pig
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181097
作者单位	Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States; Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, United States; Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, United States
推荐引用方式 GB/T 7714	Haddock E.,Saturday G.,Feldmann F.,et al. Reston virus causes severe respiratory disease in young domestic pigs[J],2021,118(2).
APA	Haddock E..,Saturday G..,Feldmann F..,Hanley P.W..,Okumura A..,...&Feldmann H..(2021).Reston virus causes severe respiratory disease in young domestic pigs.Proceedings of the National Academy of Sciences of the United States of America,118(2).
MLA	Haddock E.,et al."Reston virus causes severe respiratory disease in young domestic pigs".Proceedings of the National Academy of Sciences of the United States of America 118.2(2021).