气候变化领域集成服务门户(CCPortal): Diurnal rhythms across the human dorsal and ventral striatum

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DOI	10.1073/pnas.2016150118
	Diurnal rhythms across the human dorsal and ventral striatum
	Ketchesin K.D.; Zong W.; Hildebrand M.A.; Seney M.L.; Cahill K.M.; Scott M.R.; Shankar V.G.; Glausier J.R.; Lewis D.A.; Tseng G.C.; McClung C.A.
发表日期	2021
ISSN	00278424
卷号	118 期号:2
英文摘要	The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). Each of these structures have some overlapping and some distinct functions related to motor control, cognitive processing, motivation, and reward. Previously, we used a “time-of-death” approach to identify diurnal rhythms in RNA transcripts in human cortical regions. Here, we identify molecular rhythms across the three striatal subregions collected from postmortem human brain tissue in subjects without psychiatric or neurological disorders. Core circadian clock genes are rhythmic across all three regions and show strong phase concordance across regions. However, the putamen contains a much larger number of significantly rhythmic transcripts than the other two regions. Moreover, there are many differences in pathways that are rhythmic across regions. Strikingly, the top rhythmic transcripts in NAc (but not the other regions) are predominantly small nucleolar RNAs and long noncoding RNAs, suggesting that a completely different mechanism might be used for the regulation of diurnal rhythms in translation and/or RNA processing in the NAc versus the other regions. Further, although the NAc and putamen are generally in phase with regard to timing of expression rhythms, the NAc and caudate, and caudate and putamen, have several clusters of discordant rhythmic transcripts, suggesting a temporal wave of specific cellular processes across the striatum. Taken together, these studies reveal distinct transcriptome rhythms across the human striatum and are an important step in helping to understand the normal function of diurnal rhythms in these regions and how disruption could lead to pathology. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Circadian rhythms; Gene expression; Human postmortem; Striatum
语种	英语
scopus关键词	initiation factor 2; interferon consensus sequence binding protein; interleukin 15; long untranslated RNA; messenger RNA; mitogen activated protein kinase 7; neu differentiation factor; protein S6; ribosome RNA; S6 kinase; sirtuin; small nucleolar RNA; transcription factor 7 like 2; transcription factor CLOCK; transcriptome; Article; cell stress; circadian rhythm; controlled study; cytokine production; dorsal striatum; energy metabolism; gene expression; human; human tissue; nucleus accumbens; oxidative stress; priority journal; protein acetylation; protein folding; protein phosphorylation; putamen; RNA processing; RNA sequencing; RNA splicing; RNA translation; signal transduction; transcription regulation; translation initiation; translation termination; ubiquitination; unfolded protein response; ventral striatum
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/181063
作者单位	Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15219, United States; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15213, United States
推荐引用方式 GB/T 7714	Ketchesin K.D.,Zong W.,Hildebrand M.A.,et al. Diurnal rhythms across the human dorsal and ventral striatum[J],2021,118(2).
APA	Ketchesin K.D..,Zong W..,Hildebrand M.A..,Seney M.L..,Cahill K.M..,...&McClung C.A..(2021).Diurnal rhythms across the human dorsal and ventral striatum.Proceedings of the National Academy of Sciences of the United States of America,118(2).
MLA	Ketchesin K.D.,et al."Diurnal rhythms across the human dorsal and ventral striatum".Proceedings of the National Academy of Sciences of the United States of America 118.2(2021).