气候变化领域集成服务门户(CCPortal): A link between synaptic plasticity and reorganization of brain activity in Parkinson’s disease

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DOI	10.1073/pnas.2013962118
	A link between synaptic plasticity and reorganization of brain activity in Parkinson’s disease
	Rebelo D.; Oliveira F.; Abrunhosa A.; Januário C.; Lemos J.; Castelo-Branco M.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	The link between synaptic plasticity and reorganization of brain activity in health and disease remains a scientific challenge. We examined this question in Parkinson’s disease (PD) where functional up-regulation of postsynaptic D2 receptors has been documented while its significance at the neural activity level has never been identified. We investigated cortico-subcortical plasticity in PD using the oculomotor system as a model to study reorganization of dopaminergic networks. This model is ideal because this system reorganizes due to frontal-to-parietal shifts in blood oxygen level–dependent (BOLD) activity. We tested the prediction that functional activation plasticity is associated with postsynaptic dopaminergic modifications by combining positron emission tomography/ functional magnetic resonance imaging to investigate striatal postsynaptic reorganization of dopamine D2 receptors (using 11C-raclopride) and neural activation in PD. We used covariance (connectivity) statistics at molecular and functional levels to probe striato-cortical reorganization in PD in on/off medication states to show that functional and molecular forms of reorganization are related. D2 binding across regions defined by prosaccades showed increased molecular connectivity between both caudate/putamen and hyperactive parietal eye fields in PD in contrast with frontal eye fields in controls, in line with the shift model. Concerning antisaccades, parietal-striatal connectivity dominated in again in PD, unlike frontal regions. Concerning molecular–BOLD covariance, a striking sign reversal was observed: PD patients showed negative frontal-putamen functional–molecular associations, consistent with the reorganization shift, in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication PD patients confirmed the negative BOLD–molecular correlation. These results provide a link among BOLD responses, striato-cortical synaptic reorganization, and neural plasticity in PD. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Functional connectivity; Functional magnetic resonance imaging; Molecular imaging; Positron emission tomography
语种	英语
scopus关键词	dopamine 2 receptor; raclopride c 11; adult; aged; Article; BOLD signal; brain cortex; clinical article; dopaminergic system; dorsal striatum; electroencephalogram; female; follow up; frontal eye field; functional magnetic resonance imaging; human; hyperactivity; male; nerve cell; nerve cell plasticity; oculomotor system; Parkinson disease; positron emission tomography; prediction; priority journal; protein binding; striate cortex; subcortex; upregulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180987
作者单位	Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, 3000-548, Portugal; Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, 3000-548, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, 3000-370, Portugal; Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, 1400-038, Portugal; Neurology Department, Coimbra University Hospital Centre, Coimbra, 3004-561, Portugal
推荐引用方式 GB/T 7714	Rebelo D.,Oliveira F.,Abrunhosa A.,等. A link between synaptic plasticity and reorganization of brain activity in Parkinson’s disease[J],2021,118(3).
APA	Rebelo D.,Oliveira F.,Abrunhosa A.,Januário C.,Lemos J.,&Castelo-Branco M..(2021).A link between synaptic plasticity and reorganization of brain activity in Parkinson’s disease.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Rebelo D.,et al."A link between synaptic plasticity and reorganization of brain activity in Parkinson’s disease".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).