气候变化领域集成服务门户(CCPortal): Fitness maps to a large-effect locus in introduced stickleback populations

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DOI	10.1073/pnas.1914889118
	Fitness maps to a large-effect locus in introduced stickleback populations
	Schluter D.; Marchinko K.B.; Arnegard M.E.; Zhang H.; Brady S.D.; Jones F.C.; Bell M.A.; Kingsley D.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Mutations of small effect underlie most adaptation to new environments, but beneficial variants with large fitness effects are expected to contribute under certain conditions. Genes and genomic regions having large effects on phenotypic differences between populations are known from numerous taxa, but fitness effect sizes have rarely been estimated. We mapped fitness over a generation in an F2 intercross between a marine and a lake stickleback population introduced to a freshwater pond. A quantitative trait locus map of the number of surviving offspring per F2 female detected a single, large-effect locus near Ectodysplasin (Eda), a gene having an ancient freshwater allele causing reduced bony armor and other changes. F2 females homozygous for the freshwater allele had twice the number of surviving offspring as homozygotes for the marine allele, producing a large selection coefficient, s = 0.50 ± 0.09 SE. Correspondingly, the frequency of the freshwater allele increased from 0.50 in F2 mothers to 0.58 in surviving offspring. We compare these results to allele frequency changes at the Eda gene in an Alaskan lake population colonized by marine stickleback in the 1980s. The frequency of the freshwater Eda allele rose steadily over multiple generations and reached 95% within 20 y, yielding a similar estimate of selection, s = 0.49 ± 0.05, but a different degree of dominance. These findings are consistent with other studies suggesting strong selection on this gene (and/or linked genes) in fresh water. Selection on ancient genetic variants carried by colonizing ancestors is likely to increase the prevalence of large-effect fitness variants in adaptive evolution. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Genetics of adaptation \| stickleback \| natural selection \| Ectodysplasin \| fitness mapping
语种	英语
scopus关键词	Article; controlled study; Eda gene; gene; gene frequency; gene mapping; gene mutation; genetic variability; homozygote; natural selection; nonhuman; priority journal; stickleback
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180984
作者单位	Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, United States; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, United States; University of California Museum of Paleontology, Berkeley, CA 94720, United States; Surrozen Inc., South San Francisco, CA 94080, United States; Friedrich Miescher Laboratory, Max Planck Society, Tübingen, 72076, Germany
推荐引用方式 GB/T 7714	Schluter D.,Marchinko K.B.,Arnegard M.E.,et al. Fitness maps to a large-effect locus in introduced stickleback populations[J],2021,118(3).
APA	Schluter D..,Marchinko K.B..,Arnegard M.E..,Zhang H..,Brady S.D..,...&Kingsley D.M..(2021).Fitness maps to a large-effect locus in introduced stickleback populations.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Schluter D.,et al."Fitness maps to a large-effect locus in introduced stickleback populations".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).