气候变化领域集成服务门户(CCPortal): Emergence of homochirality in large molecular systems

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DOI	10.1073/pnas.2012741118
	Emergence of homochirality in large molecular systems
	Laurent G.; Lacoste D.; Gaspard P.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	The selection of a single molecular handedness, or homochirality across all living matter, is a mystery in the origin of life. Frank’s seminal model showed in the’50s how chiral symmetry breaking can occur in nonequilibrium chemical networks. However, an important shortcoming in this classic model is that it considers a small number of species, while there is no reason for the prebiotic system, in which homochirality first appeared, to have had such a simple composition. Furthermore, this model does not provide information on what could have been the size of the molecules involved in this homochiral prebiotic system. Here, we show that large molecular systems are likely to undergo a phase transition toward a homochiral state, as a consequence of the fact that they contain a large number of chiral species. Using chemoinformatics tools, we quantify how abundant chiral species are in the chemical universe of all possible molecules of a given length. Then, we propose that Frank’s model should be extended to include a large number of species, in order to possess the transition toward homochirality, as confirmed by numerical simulations. Finally, using random matrix theory, we prove that large nonequilibrium reaction networks possess a generic and robust phase transition toward a homochiral state. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Homochirality; Origin of life; Prebiotic chemistry; Random matrices; Statistical physics
语种	英语
scopus关键词	alkane; carbon; prebiotic agent; Article; atom; chemical reaction; cheminformatics; chirality; controlled study; crossing over; homochirality; molecular mechanics; phase transition; priority journal; racemic mixture; simulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180971
作者单位	Gulliver, UMR CNRS 7083, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris Sciences et Lettres Research University, Paris, F-75231, France; Center for Nonlinear Phenomena and Complex Systems, Université Libre de Bruxelles, Brussels, B-1050, Belgium
推荐引用方式 GB/T 7714	Laurent G.,Lacoste D.,Gaspard P.. Emergence of homochirality in large molecular systems[J],2021,118(3).
APA	Laurent G.,Lacoste D.,&Gaspard P..(2021).Emergence of homochirality in large molecular systems.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Laurent G.,et al."Emergence of homochirality in large molecular systems".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).