气候变化领域集成服务门户(CCPortal): Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection

CCPortal

DOI	10.1073/pnas.2015080118
	Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection
	Ezenwa V.O.; Budischak S.A.; Buss P.; Seguel M.; Luikart G.; Jolles A.E.; Sakamoto K.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Pathogen interactions arising during coinfection can exacerbate disease severity, for example when the immune response mounted against one pathogen negatively affects defense of another. It is also possible that host immune responses to a pathogen, shaped by historical evolutionary interactions between host and pathogen, may modify host immune defenses in ways that have repercussions for other pathogens. In this case, negative interactions between two pathogens could emerge even in the absence of concurrent infection. Parasitic worms and tuberculosis (TB) are involved in one of the most geographically extensive of pathogen interactions, and during coinfection worms can exacerbate TB disease outcomes. Here, we show that in a wild mammal natural resistance to worms affects bovine tuberculosis (BTB) severity independently of active worm infection. We found that worm-resistant individuals were more likely to die of BTB than were nonresistant individuals, and their disease progressed more quickly. Anthelmintic treatment moderated, but did not eliminate, the resistance effect, and the effects of resistance and treatment were opposite and additive, with untreated, resistant individuals experiencing the highest mortality. Furthermore, resistance and anthelmintic treatment had nonoverlapping effects on BTB pathology. The effects of resistance manifested in the lungs (the primary site of BTB infection), while the effects of treatment manifested almost entirely in the lymph nodes (the site of disseminated disease), suggesting that resistance and active worm infection affect BTB progression via distinct mechanisms. Our findings reveal that interactions between pathogens can occur as a consequence of processes arising on very different timescales. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	African buffalo \| coinfection \| helminths \| resistance \| tuberculosis
语种	英语
scopus关键词	anthelmintic agent; African buffalo; animal experiment; animal tissue; antihelminthic therapy; Article; bovine tuberculosis; cohort analysis; controlled study; disease course; disease exacerbation; disease severity; fecal egg count; female; helminthiasis; host pathogen interaction; incidence; infection resistance; lymph node; microbial genetics; mixed infection; mortality; nonhuman; priority journal; South Africa; wild animal
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180970
作者单位	Odum School of Ecology, University of Georgia, Athens, GA 30602, United States; Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States; Veterinary Wildlife Services, South African National Parks, Skukuza, 1350, South Africa; Flathead Lake Biological Station, Division of Biological Sciences, University of Montana, Missoula, MT 59812, United States; College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, United States; Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, United States; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States; W. M. Keck Science Department, Claremont McKenna, Pitzer,, Scripps Colleges, Claremont, CA 91711, United States; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON NIG 2W1, Canada
推荐引用方式 GB/T 7714	Ezenwa V.O.,Budischak S.A.,Buss P.,et al. Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection[J],2021,118(3).
APA	Ezenwa V.O..,Budischak S.A..,Buss P..,Seguel M..,Luikart G..,...&Sakamoto K..(2021).Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Ezenwa V.O.,et al."Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).