气候变化领域集成服务门户(CCPortal): Diversification of mammalian deltaviruses by host shifting

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DOI	10.1073/pnas.2019907118
	Diversification of mammalian deltaviruses by host shifting
	Bergner L.M.; Orton R.J.; Broos A.; Tello C.; Becker D.J.; Carrera J.E.; Patel A.H.; Biek R.; Streicker D.G.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Hepatitis delta virus (HDV) is an unusual RNA agent that replicates using host machinery but exploits hepatitis B virus (HBV) to mobilize its spread within and between hosts. In doing so, HDV enhances the virulence of HBV. How this seemingly improbable hyperparasitic lifestyle emerged is unknown, but it underpins the likelihood that HDV and related deltaviruses may alter other host–virus interactions. Here, we show that deltaviruses diversify by transmitting between mammalian species. Among 96,695 RNA sequence datasets, deltaviruses infected bats, rodents, and an artiodactyl from the Americas but were absent from geographically overrepresented Old World representatives of each mammalian order, suggesting a relatively recent diversification within the Americas. Consistent with diversification by host shifting, both bat and rodent-infecting deltaviruses were paraphyletic, and coevolutionary modeling rejected cospeciation with mammalian hosts. In addition, a 2-y field study showed common vampire bats in Peru were infected by two divergent deltaviruses, indicating multiple introductions to a single host species. One vampire bat-associated deltavirus was detected in the saliva of up to 35% of individuals, formed phylogeographically compartmentalized clades, and infected a sympatric bat, illustrating horizontal transmission within and between species on ecological timescales. Consistent absence of HBV-like viruses in two deltavirus-infected bat species indicated acquisitions of novel viral associations during the divergence of bat and human-infecting deltaviruses. Our analyses support an American zoonotic origin of HDV and reveal prospects for future cross-species emergence of deltaviruses. Given their peculiar life history, deltavirus host shifts will have different constraints and disease outcomes compared to ordinary animal pathogens. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Satellite virus \| hepatitis delta virus \| zoonosis \| host shifting
语种	英语
scopus关键词	adult; Article; Artiodactyla; bat; bioinformatics; blood sampling; cohort analysis; controlled study; female; genetic screening; genetic variability; Hepatitis delta virus; human; male; mammal; metagenomics; molecular genetics; nonhuman; paraphyly; Peru; phylogeny; phylogeography; priority journal; real time polymerase chain reaction; RNA sequence; saliva analysis; species diversity; virus detection; virus infection; virus transmission
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180968
作者单位	Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom; Medical Research Center, University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, United Kingdom; Association for the Conservation and Development of Natural Resources, Lima, 15037, Peru; Yunkawasi, Lima, 15049, Peru; Department of Biology, University of Oklahoma, Norman, OK 73019, United States; Departamento de Mastozoología, Museo de Historia Natural, Universidad Nacional Mayor de San Marcos, Lima, 15081, Peru; Programa de Conservación de Murciélagos de Perú, Piura, 20001, Peru
推荐引用方式 GB/T 7714	Bergner L.M.,Orton R.J.,Broos A.,et al. Diversification of mammalian deltaviruses by host shifting[J],2021,118(3).
APA	Bergner L.M..,Orton R.J..,Broos A..,Tello C..,Becker D.J..,...&Streicker D.G..(2021).Diversification of mammalian deltaviruses by host shifting.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Bergner L.M.,et al."Diversification of mammalian deltaviruses by host shifting".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).