气候变化领域集成服务门户(CCPortal): Modulation of immune cell reactivity with cis-binding Siglec agonists

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DOI	10.1073/pnas.2012408118
	Modulation of immune cell reactivity with cis-binding Siglec agonists
	Delaveris C.S.; Chiu S.H.; Riley N.M.; Bertozzi C.R.
发表日期	2021
ISSN	00278424
卷号	118 期号:3
英文摘要	Inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions, including chronic pain and blindness due to age-related macular degeneration. Many members of the sialic acid-binding immunoglobulin-like lectin (Siglec) family are immunoinhibitory receptors whose agonism is an attractive approach for antiinflammatory therapy. Here, we show that synthetic lipid-conjugated glycopolypeptides can insert into cell membranes and engage Siglec receptors in cis, leading to inhibitory signaling. Specifically, we construct a cis-binding agonist of Siglec-9 and show that it modulates mitogen-activated protein kinase (MAPK) signaling in reporter cell lines, immortalized macrophage and microglial cell lines, and primary human macrophages. Thus, these cis-binding agonists of Siglecs present a method for therapeutic suppression of immune cell reactivity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Glycocalyx; Glycopolymer; Immunotherapy; Inflammation; Siglec
语种	英语
scopus关键词	glycopolypeptide; mitogen activated protein kinase; polypeptide; protein Siclec 9; sialic acid binding immunoglobulin like lectin; unclassified drug; Article; cell activation; cell membrane; controlled study; human; human cell; immunocompetent cell; inflammatory disease; macrophage cell line; MAPK signaling; microglial cell line; priority journal
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180954
作者单位	Department of Chemistry, Stanford University, Stanford, CA 94305, United States; Stanford ChEM-H, Stanford University, Stanford, CA 94305, United States; HHMI, Stanford University, Stanford, CA 94305, United States
推荐引用方式 GB/T 7714	Delaveris C.S.,Chiu S.H.,Riley N.M.,et al. Modulation of immune cell reactivity with cis-binding Siglec agonists[J],2021,118(3).
APA	Delaveris C.S.,Chiu S.H.,Riley N.M.,&Bertozzi C.R..(2021).Modulation of immune cell reactivity with cis-binding Siglec agonists.Proceedings of the National Academy of Sciences of the United States of America,118(3).
MLA	Delaveris C.S.,et al."Modulation of immune cell reactivity with cis-binding Siglec agonists".Proceedings of the National Academy of Sciences of the United States of America 118.3(2021).