气候变化领域集成服务门户(CCPortal): Accumulation of styrene oligomers alters lipid membrane phase order and miscibility

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DOI	10.1073/pnas.2016037118
	Accumulation of styrene oligomers alters lipid membrane phase order and miscibility
	Morandi M.I.; Kluzek M.; Wolff J.; Schroder A.; Thalmann F.; Marques C.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:4
英文摘要	Growth of plastic waste in the natural environment, and in particular in the oceans, has raised the accumulation of polystyrene and other polymeric species in eukyarotic cells to the level of a credible and systemic threat. Oligomers, the smallest products of polymer degradation or incomplete polymerization reactions, are the first species to leach out of macroscopic or nanoscopic plastic materials. However, the fundamental mechanisms of interaction between oligomers and polymers with the different cell components are yet to be elucidated. Simulations performed on lipid bilayers showed changes in membrane mechanical properties induced by polystyrene, but experimental results performed on cell membranes or on cell membrane models are still missing. We focus here on understanding how embedded styrene oligomers affect the phase behavior of model membranes using a combination of scattering, fluorescence, and calorimetric techniques. Our results show that styrene oligomers disrupt the phase behavior of lipid membranes, modifying the thermodynamics of the transition through a spatial modulation of lipid composition. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Laurdan; Lipid bilayer phase separation; Nanopollution; SANS
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180915
作者单位	Institut Charles Sadron, Université de Strasbourg, CNRS, UPR022, Strasbourg Cedex, 67034, France
推荐引用方式 GB/T 7714	Morandi M.I.,Kluzek M.,Wolff J.,et al. Accumulation of styrene oligomers alters lipid membrane phase order and miscibility[J],2021,118(4).
APA	Morandi M.I.,Kluzek M.,Wolff J.,Schroder A.,Thalmann F.,&Marques C.M..(2021).Accumulation of styrene oligomers alters lipid membrane phase order and miscibility.Proceedings of the National Academy of Sciences of the United States of America,118(4).
MLA	Morandi M.I.,et al."Accumulation of styrene oligomers alters lipid membrane phase order and miscibility".Proceedings of the National Academy of Sciences of the United States of America 118.4(2021).