气候变化领域集成服务门户(CCPortal): Evolution in the weak-mutation limit: Stasis periods punctuated by fast transitions between saddle points on the fitness landscape

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DOI	10.1073/pnas.2015665118
	Evolution in the weak-mutation limit: Stasis periods punctuated by fast transitions between saddle points on the fitness landscape
	Bakhtin Y.; Katsnelson M.I.; Wolf Y.I.; Koonin E.V.
发表日期	2021
ISSN	00278424
卷号	118 期号:4
英文摘要	A mathematical analysis of the evolution of a large population under the weak-mutation limit shows that such a population would spend most of the time in stasis in the vicinity of saddle points on the fitness landscape. The periods of stasis are punctuated by fast transitions, in lnNe/s time (Ne, effective population size; s, selection coefficient of a mutation), when a new beneficial mutation is fixed in the evolving population, which accordingly moves to a different saddle, or on much rarer occasions from a saddle to a local peak. Phenomenologically, this mode of evolution of a large population resembles punctuated equilibrium (PE) whereby phenotypic changes occur in rapid bursts that are separated by much longer intervals of stasis during which mutations accumulate but the phenotype does not change substantially. Theoretically, PE has been linked to self-organized criticality (SOC), a model in which the size of “avalanches” in an evolving system is power-law-distributed, resulting in increasing rarity of major events. Here we show, however, that a PE-like evolutionary regime is the default for a very simple model of an evolving population that does not rely on SOC or any other special conditions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Fitness landscapes; Low mutation limit; Punctuated equilibrium; Saddle points; Self-organized criticality
语种	英语
scopus关键词	article; avalanche; theoretical study
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180905
作者单位	Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, United States; Institute for Molecules and Materials, Radboud University, Nijmegen, NL-6525 AJ, Netherlands; National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, United States
推荐引用方式 GB/T 7714	Bakhtin Y.,Katsnelson M.I.,Wolf Y.I.,et al. Evolution in the weak-mutation limit: Stasis periods punctuated by fast transitions between saddle points on the fitness landscape[J],2021,118(4).
APA	Bakhtin Y.,Katsnelson M.I.,Wolf Y.I.,&Koonin E.V..(2021).Evolution in the weak-mutation limit: Stasis periods punctuated by fast transitions between saddle points on the fitness landscape.Proceedings of the National Academy of Sciences of the United States of America,118(4).
MLA	Bakhtin Y.,et al."Evolution in the weak-mutation limit: Stasis periods punctuated by fast transitions between saddle points on the fitness landscape".Proceedings of the National Academy of Sciences of the United States of America 118.4(2021).