气候变化领域集成服务门户(CCPortal): The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis

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DOI	10.1073/pnas.2016878118
	The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis
	Zhang C.; Daubnerova I.; Jang Y.-H.; Kondo S.; Žitnan D.; Kim Y.-J.
发表日期	2021
ISSN	00278424
卷号	118 期号:4
英文摘要	The link between the biological clock and reproduction is evident in most metazoans. The fruit fly Drosophila melanogaster, a key model organism in the field of chronobiology because of its well-defined networks of molecular clock genes and pacemaker neurons in the brain, shows a pronounced diurnal rhythmicity in oogenesis. Still, it is unclear how the circadian clock generates this reproductive rhythm. A subset of the group of neurons designated “posterior dorsal neuron 1” (DN1p), which are among the ∼150 pacemaker neurons in the fly brain, produces the neuropeptide allatostatin C (AstC-DN1p). Here, we report that six pairs of AstC-DN1p send inhibitory inputs to the brain insulin-producing cells, which express two AstC receptors, star1 and AICR2. Consistent with the roles of insulin/insulin-like signaling in oogenesis, activation of AstC-DN1p suppresses oogenesis through the insulin-producing cells. We show evidence that AstC-DN1p activity plays a role in generating an oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin/insulin-like signaling. AstC is orthologous to the vertebrate neuropeptide somatostatin (SST). Like AstC, SST inhibits gonadotrophin secretion indirectly through gonadotropin-releasing hormone neurons in the hypothalamus. The functional and structural conservation linking the AstC and SST systems suggest an ancient origin for the neural substrates that generate reproductive rhythms. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Biological clock; Drosophila; Insulin; Somatostatin; Vitellogenesis
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180879
作者单位	School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; Institute of Zoology, Slovak Academy of Sciences, Bratislava, 84506, Slovakia; Invertebrate Genetics Laboratory, National Institute of Genetics, Shizuoka, 411-8540, Japan
推荐引用方式 GB/T 7714	Zhang C.,Daubnerova I.,Jang Y.-H.,et al. The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis[J],2021,118(4).
APA	Zhang C.,Daubnerova I.,Jang Y.-H.,Kondo S.,Žitnan D.,&Kim Y.-J..(2021).The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis.Proceedings of the National Academy of Sciences of the United States of America,118(4).
MLA	Zhang C.,et al."The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis".Proceedings of the National Academy of Sciences of the United States of America 118.4(2021).