气候变化领域集成服务门户(CCPortal): Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset

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DOI	10.1073/pnas.2021615118
	Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset
	Sasisekharan V.; Pentakota N.; Jayaraman A.; Tharakaraman K.; Wogan G.N.; Narayanasami U.
发表日期	2021
ISSN	00278424
卷号	118 期号:5
英文摘要	Immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the current pandemic remains a field of immense interest and active research worldwide. Although the severity of acute infection may depend on the intensity of innate and adaptive immunity, leading to higher morbidity and mortality, the longevity of IgG antibodies, including neutralizing activity to SARS-CoV-2, is viewed as a key correlate of immune protection. Amid reports and concern that there is a rapid decay of IgG antibody levels within 1 mo to 2 mo after acute infection, we set out to study the pattern and duration of IgG antibody response to various SARS-CoV-2 antigens in asymptomatic and symptomatic patients in a community setting. Herein, we show the correlation of IgG anti-spike protein S1 subunit, receptor binding domain, nucleocapsid, and virus neutralizing antibody titers with each other and with clinical features such as length and severity of COVID-19 illness. More importantly, using orthogonal measurements, we found the IgG titers to persist for more than 4 mo post symptom onset, implying that long-lasting immunity to COVID-19 from infection or vaccination might be observed, as seen with other coronaviruses such as SARS and Middle East respiratory syndrome. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Antigens; Immunity; Orthogonal; SARS-CoV-2
语种	英语
scopus关键词	immunoglobulin G; virus antibody; adult; blood; female; human; humoral immunity; immunoassay; immunology; longitudinal study; male; middle aged; Adult; Antibodies, Viral; COVID-19; Female; Humans; Immunity, Humoral; Immunoassay; Immunoglobulin G; Longitudinal Studies; Male; Middle Aged; SARS-CoV-2
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180842
作者单位	Discovery and Diagnostics Division, Peritia Inc., Woburn, MA 01801, United States; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Massachusetts General Hospital Cancer Center, Emerson Hospital, Concord, MA 01742, United States
推荐引用方式 GB/T 7714	Sasisekharan V.,Pentakota N.,Jayaraman A.,et al. Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset[J],2021,118(5).
APA	Sasisekharan V.,Pentakota N.,Jayaraman A.,Tharakaraman K.,Wogan G.N.,&Narayanasami U..(2021).Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset.Proceedings of the National Academy of Sciences of the United States of America,118(5).
MLA	Sasisekharan V.,et al."Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset".Proceedings of the National Academy of Sciences of the United States of America 118.5(2021).