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| DOI | 10.1073/pnas.2010217118 |
| The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome | |
| Brett Finlay B.; Amato K.R.; Azad M.; Blaser M.J.; Bosch T.C.G.; Chu H.; Dominguez-Bello M.G.; Ehrlich S.D.; Elinav E.; Geva-Zatorsky N.; Gros P.; Guillemin K.; Keck F.; Korem T.; McFall-Ngai M.J.; Melby M.K.; Nichter M.; Pettersson S.; Poinar H.; Rees T.; Tropini C.; Zhao L.; Giles-Vernick T. | |
| Date Issued | 2021 |
| ISSN | 00278424 |
| Volume | 118Issue:6 |
| Other Abstract | The COVID-19 pandemic has the potential to affect the human microbiome in infected and uninfected individuals, having a substantial impact on human health over the long term. This pandemic intersects with a decades-long decline in microbial diversity and ancestral microbes due to hygiene, antibiotics, and urban living (the hygiene hypothesis). High-risk groups succumbing to COVID-19 include those with preexisting conditions, such as diabetes and obesity, which are also associated with microbiome abnormalities. Current pandemic control measures and practices will have broad, uneven, and potentially long-term effects for the human microbiome across the planet, given the implementation of physical separation, extensive hygiene, travel barriers, and other measures that influence overall microbial loss and inability for reinoculation. Although much remains uncertain or unknown about the virus and its consequences, implementing pandemic control practices could significantly affect the microbiome. In this Perspective, we explore many facets of COVID-19−induced societal changes and their possible effects on the microbiome, and discuss current and future challenges regarding the interplay between this pandemic and the microbiome. Recent recognition of the microbiome's influence on human health makes it critical to consider both how the microbiome, shaped by biosocial processes, affects susceptibility to the coronavirus and, conversely, how COVID-19 disease and prevention measures may affect the microbiome. This knowledge may prove key in prevention and treatment, and long-term biological and social outcomes of this pandemic. © 2021 National Academy of Sciences. All rights reserved. |
| enkeywords | COVID-19; Hygiene hypothesis; Microbiome |
| Language | 英语 |
| scopus keywords | antiinfective agent; aged; drug effect; eating; female; human; hygiene hypothesis; infant; infection control; male; microbiology; microflora; mortality; pregnancy; procedures; Aged; Anti-Infective Agents; COVID-19; Eating; Female; Humans; Hygiene Hypothesis; Infant; Infection Control; Male; Microbiota; Physical Distancing; Pregnancy |
| journal | Proceedings of the National Academy of Sciences of the United States of America
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| Document Type | 期刊论文 |
| Identifier | http://gcip.llas.ac.cn/handle/2XKMVOVA/180782 |
| Affiliation | Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada; Department of Anthropology, Northwestern University, Evanston, IL 60208, United States; Manitoba Interdisciplinary Lactation Centre, Children's Hospital Research, Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada; Center for Advanced Biotechnology and Medicine at Rutgers Biomedical and Health Sciences, Rutgers University, Piscataway, NJ 08854-8021, United States; Zoologisches Institut, University of Kiel, Kiel, 24118, Germany; Department of Pathology, University of California San Diego, San Diego, CA 92093, United States; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, United States; Metagenopolis Unit, French National Institute for Agricultural Research, Jouy-en-Josas, 78350, France; Department of Immunology, Weizmann Institute of Science, Rehovot, 761000, Isra... |
| Recommended Citation GB/T 7714 | Brett Finlay B.,Amato K.R.,Azad M.,et al. The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome[J],2021,118(6). |
| APA | Brett Finlay B..,Amato K.R..,Azad M..,Blaser M.J..,Bosch T.C.G..,...&Giles-Vernick T..(2021).The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome.Proceedings of the National Academy of Sciences of the United States of America,118(6). |
| MLA | Brett Finlay B.,et al."The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021). |
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