气候变化领域集成服务门户(CCPortal): The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis

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DOI	10.1073/pnas.2024592118
	The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis
	Hao D.; Jin L.; Wen X.; Yu F.; Xie Q.; Guo H.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	The gaseous phytohormone ethylene mediates numerous aspects of plant growth and development as well as stress responses. The F-box proteins EIN3-binding F-box protein 1 (EBF1) and EBF2 are key components that ubiquitinate and degrade the master transcription factors ethylene insensitive 3 (EIN3) and EIN3-like 1 (EIL1) in the ethylene response pathway. Notably, EBF1 and EBF2 themselves undergo the 26S proteasome-mediated proteolysis induced by ethylene and other stress signals. However, despite their importance, little is known about the mechanisms regulating the degradation of these proteins. Here, we show that a really interesting new gene (RING)-type E3 ligase, salt- and drought-induced ring finger 1 (SDIR1), positively regulates the ethylene response and promotes the accumulation of EIN3. Further analyses indicate that SDIR1 directly interacts with EBF1/EBF2 and targets them for ubiquitination and proteasome-dependent degradation. We show that SDIR1 is required for the fine tuning of the ethylene response to ambient temperature changes by mediating temperature-induced EBF1/EBF2 degradation and EIN3 accumulation. Thus, our work demonstrates that SDIR1 functions as an important modulator of ethylene signaling in response to ambient temperature changes, thereby enabling plant adaptation under fluctuating environmental conditions. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Ambient temperature; EBF1/EBF2; Ethylene; SDIR1; Ubiquitination
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180771
作者单位	Institute of Plant and Food Science, Department of Biology, Southern University of Science and Technology, Shenzhen, 518055, China; Key Laboratory of Molecular Design for Plant Cell Factory, Guangdong Higher Education Institutes, Southern University of Science and Technology, Shenzhen, 518055, China; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China
推荐引用方式 GB/T 7714	Hao D.,Jin L.,Wen X.,et al. The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis[J],2021,118(6).
APA	Hao D.,Jin L.,Wen X.,Yu F.,Xie Q.,&Guo H..(2021).The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Hao D.,et al."The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).