气候变化领域集成服务门户(CCPortal): Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

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DOI	10.1073/pnas.2006980118
	Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane
	Sorum B.; Rietmeijer R.A.; Gopakumar K.; Adesnik H.; Brohawn S.G.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	Ultrasound modulates the electrical activity of excitable cells and offers advantages over other neuromodulatory techniques; for example, it can be noninvasively transmitted through the skull and focused to deep brain regions. However, the fundamental cellular, molecular, and mechanistic bases of ultrasonic neuromodulation are largely unknown. Here, we demonstrate ultrasound activation of the mechanosensitive K+ channel TRAAK with submillisecond kinetics to an extent comparable to canonical mechanical activation. Single-channel recordings reveal a common basis for ultrasonic and mechanical activation with stimulus-graded destabilization of long-duration closures and promotion of full conductance openings. Ultrasonic energy is transduced to TRAAK through the membrane in the absence of other cellular components, likely increasing membrane tension to promote channel opening. We further demonstrate ultrasonic modulation of neuronally expressed TRAAK. These results suggest mechanosensitive channels underlie physiological responses to ultrasound and could serve as sonogenetic actuators for acoustic neuromodulation of genetically targeted cells. © This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
英文关键词	K2P ion channels; Mechanosensation; Neuromodulation; Sonogenetics; Ultrasound
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180743
作者单位	Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, United States; Biophysics Graduate Program, University of California, Berkeley, CA 94720, United States
推荐引用方式 GB/T 7714	Sorum B.,Rietmeijer R.A.,Gopakumar K.,et al. Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane[J],2021,118(6).
APA	Sorum B.,Rietmeijer R.A.,Gopakumar K.,Adesnik H.,&Brohawn S.G..(2021).Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Sorum B.,et al."Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).