气候变化领域集成服务门户(CCPortal): Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10

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DOI	10.1073/pnas.2002787118
	Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10
	Muñoz M.; Hegazy A.N.; Brunner T.M.; Holecska V.; Marek R.M.; Fröhlich A.; Löhning M.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	Exacerbated immune responses and loss of self-tolerance lead to the development of autoimmunity and immunopathology. Novel therapies to target autoreactive T cells are still needed. Here, we report that Th2-polarized T cells lacking the transcription factor T-bet harbor strong immunomodulatory potential and suppress antigen-specific CD8+ T cells via IL-10. Tbx21−/− Th2 cells protected mice against virus-induced type 1 diabetes development and suppressed not only naive but also memory CD8+ T cell responses. IL-10-producing, but not IL-10-deficient Tbx21−/− Th2 cells down-regulated costimulatory molecules on dendritic cells and reduced their IL-12 production after lymphocytic choriomeningitis virus infection. Impaired dendritic cell activation hindered effector and cytotoxic CD8+ T cell development after infection. These findings indicate that Tbx21−/− Th2 cells strongly suppress proinflammatory responses of naive and memory T cells via IL-10. Thus, in vivo IL-10-secreting Th2 cells could harbor a therapeutic potential for the treatment of T cell-mediated inflammatory disorders. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Autoimmunity; CD8+ T cells; IL-10; Memory responses; T-bet
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180711
作者单位	Experimental Immunology and Osteoarthritis Research, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany; Pitzer Laboratory of Osteoarthritis Research, German Rheumatism Research Center, Leibniz Institutes, Berlin, 10117, Germany; Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany; Clinician Scientist Program, Berlin Institute of Health, Berlin, 10178, Germany; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, 12203, Germany
推荐引用方式 GB/T 7714	Muñoz M.,Hegazy A.N.,Brunner T.M.,et al. Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10[J],2021,118(6).
APA	Muñoz M..,Hegazy A.N..,Brunner T.M..,Holecska V..,Marek R.M..,...&Löhning M..(2021).Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Muñoz M.,et al."Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).