气候变化领域集成服务门户(CCPortal): Macrophages inhibit and enhance endometriosis depending on their origin

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DOI	10.1073/pnas.2013776118
	Macrophages inhibit and enhance endometriosis depending on their origin
	Hogg C.; Panir K.; Dhami P.; Rosser M.; Mack M.; Soong D.; Pollard J.W.; Jenkins S.J.; Horne A.W.; Greaves E.
发表日期	2021
ISSN	00278424
卷号	118 期号:6
英文摘要	Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monocyte and macrophage depletion strategies we determined the ontogeny and function of macrophages in a mouse model of induced endometriosis. We demonstrate that lesion-resident macrophages are derived from eutopic endometrial tissue, infiltrating large peritoneal macrophages (LpM) and monocytes. Furthermore, we found endometriosis to trigger continuous recruitment of monocytes and expansion of CCR2+ LpM. Depletion of eutopic endometrial macrophages results in smaller endometriosis lesions, whereas constitutive inhibition of monocyte recruitment significantly reduces peritoneal macrophage populations and increases the number of lesions. Reprogramming the ontogeny of peritoneal macrophages such that embryo-derived LpM are replaced by monocyte-derived LpM decreases the number of lesions that develop. We propose a putative model whereby endometrial macrophages are “proendometriosis” while newly recruited monocyte-derived macrophages, possibly in LpM form, are “antiendometriosis.” These observations highlight the importance of monocyte-derived macrophages in limiting disease progression. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Lesion; Ontogeny; Phenotype
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180703
作者单位	Medical Research Council Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom; Centre for Early Life, Warwick Medical School, University of Warwick, Coventry, CV2 2DX, United Kingdom; Department of Internal Medicine II-Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom
推荐引用方式 GB/T 7714	Hogg C.,Panir K.,Dhami P.,et al. Macrophages inhibit and enhance endometriosis depending on their origin[J],2021,118(6).
APA	Hogg C..,Panir K..,Dhami P..,Rosser M..,Mack M..,...&Greaves E..(2021).Macrophages inhibit and enhance endometriosis depending on their origin.Proceedings of the National Academy of Sciences of the United States of America,118(6).
MLA	Hogg C.,et al."Macrophages inhibit and enhance endometriosis depending on their origin".Proceedings of the National Academy of Sciences of the United States of America 118.6(2021).