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DOI	10.1073/pnas.2015488118
	Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration
	Preisig B.C.; Riecke L.; Sjerps M.J.; Kösem A.; Kop B.R.; Bramson B.; Hagoort P.; Hervais-Adelman A.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Brain connectivity plays a major role in the encoding, transfer, and integration of sensory information. Interregional synchronization of neural oscillations in the γ-frequency band has been suggested as a key mechanism underlying perceptual integration. In a recent study, we found evidence for this hypothesis showing that the modulation of interhemispheric oscillatory synchrony by means of bihemispheric high-density transcranial alternating current stimulation (HD-TACS) affects binaural integration of dichotic acoustic features. Here, we aimed to establish a direct link between oscillatory synchrony, effective brain connectivity, and binaural integration. We experimentally manipulated oscillatory synchrony (using bihemispheric γ-TACS with different interhemispheric phase lags) and assessed the effect on effective brain connectivity and binaural integration (as measured with functional MRI and a dichotic listening task, respectively). We found that TACS reduced intrahemispheric connectivity within the auditory cortices and antiphase (interhemispheric phase lag 180°) TACS modulated connectivity between the two auditory cortices. Importantly, the changes in intra- and interhemispheric connectivity induced by TACS were correlated with changes in perceptual integration. Our results indicate that γ-band synchronization between the two auditory cortices plays a functional role in binaural integration, supporting the proposed role of interregional oscillatory synchrony in perceptual integration. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Speech perception \| transcranial alternating current stimulation \| fMRI \| dynamic causal modeling \| dichotic listening
语种	英语
scopus关键词	article; auditory cortex; causal modeling; dichotic listening; functional magnetic resonance imaging; human; speech perception; transcranial alternating current stimulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180642
作者单位	Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, 6500 HB, Netherlands; Max Planck Institute for Psycholinguistics, Nijmegen, 6525 XD, Netherlands; Department of Psychology, Neurolinguistics, University of Zurich, Zurich, 8050, Switzerland; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, 6229 GT, Netherlands; Lyon Neuroscience Research Center, Cognition Computation and Neurophysiology Team, Université Claude Bernard Lyon 1, Bron, 69500, France; Neuroscience Center Zurich, University of Zurich, Eidgenössische Technische Hochschule Zurich, Zurich, 8057, Switzerland
推荐引用方式 GB/T 7714	Preisig B.C.,Riecke L.,Sjerps M.J.,et al. Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration[J],2021,118(7).
APA	Preisig B.C..,Riecke L..,Sjerps M.J..,Kösem A..,Kop B.R..,...&Hervais-Adelman A..(2021).Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Preisig B.C.,et al."Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).