气候变化领域集成服务门户(CCPortal): Prolonged anesthesia alters brain synaptic architecture

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DOI	10.1073/pnas.2023676118
	Prolonged anesthesia alters brain synaptic architecture
	Wenzel M.; Leunig A.; Han S.; Peterka D.S.; Yuste R.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Prolonged medically induced coma (pMIC) is carried out routinely in intensive care medicine. pMIC leads to cognitive impairment, yet the underlying neuromorphological correlates are still unknown, as no direct studies of MIC exceeding ∼6 h on neural circuits exist. Here, we establish pMIC (up to 24 h) in adolescent and mature mice, and combine longitudinal two-photon imaging of cortical synapses with repeated behavioral object recognition assessments. We find that pMIC affects object recognition, and that it is associated with enhanced synaptic turnover, generated by enhanced synapse formation during pMIC, while the postanesthetic period is dominated by synaptic loss. Our results demonstrate major side effects of prolonged anesthesia on neural circuit structure. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Anesthesia \| dendritic spines \| synaptic plasticity \| memory deficit \| two-photon imaging
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180638
作者单位	Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, NY 10027, United States; Department of Epileptology, University of Bonn, Bonn, 53127, Germany
推荐引用方式 GB/T 7714	Wenzel M.,Leunig A.,Han S.,et al. Prolonged anesthesia alters brain synaptic architecture[J],2021,118(7).
APA	Wenzel M.,Leunig A.,Han S.,Peterka D.S.,&Yuste R..(2021).Prolonged anesthesia alters brain synaptic architecture.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Wenzel M.,et al."Prolonged anesthesia alters brain synaptic architecture".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).