气候变化领域集成服务门户(CCPortal): The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

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DOI	10.1073/pnas.2010632118
	The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS
	Orkin J.D.; Montague M.J.; Tejada-Martinez D.; de Manuel M.; del Campo J.; Hernandez S.C.; Fiore A.D.; Fontsere C.; Hodgson J.A.; Janiak M.C.; Kuderna L.F.K.; Lizano E.; Martin M.P.; Niimura Y.; Perry G.H.; Valverde C.S.; Tang J.; Warren W.C.; de Magalhães J.P.; Kawamura S.; Marquès-Bonet T.; Krawetz R.; Melin A.D.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, and comparative genomics offers an efficient and effective tool for generating new insights into the evolution of such traits. Studies of capuchin monkeys are particularly well situated to shed light on the selective pressures and genetic underpinnings of local adaptation to diverse habitats, longevity, and brain development. Distributed widely across Central and South America, they are inventive and extractive foragers, known for their sensorimotor intelligence. Capuchins have among the largest relative brain size of any monkey and a lifespan that exceeds 50 y, despite their small (3 to 5 kg) body size. We assemble and annotate a de novo reference genome for Cebus imitator. Through high-depth sequencing of DNA derived from blood, various tissues, and feces via fluorescence-activated cell sorting (fecalFACS) to isolate monkey epithelial cells, we compared genomes of capuchin populations from tropical dry forests and lowland rainforests and identified population divergence in genes involved in water balance, kidney function, and metabolism. Through a comparative genomics approach spanning a wide diversity of mammals, we identified genes under positive selection associated with longevity and brain development. Additionally, we provide a technological advancement in the use of noninvasive genomics for studies of free-ranging mammals. Our intra- and interspecific comparative study of capuchin genomics provides insights into processes underlying local adaptation to diverse and physiologically challenging environments, as well as the molecular basis of brain evolution and longevity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Brain size \| longevity \| seasonality \| noninvasive genomics \| flow cytometry
语种	英语
scopus关键词	animal cell; animal experiment; article; body size; brain development; brain size; Cebus; comparative genomics; comparative study; controlled study; epithelium cell; feces; flow cytometry; fluid balance; fluorescence activated cell sorting; kidney function; lifespan; local adaptation; longevity; nonhuman; rain forest; seasonal variation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180617
作者单位	Department of Anthropology and Archaeology, University of Calgary, Calgary, AB T2N 1N4, Canada; Institut de Biologia Evolutiva, Universitat Pompeu Fabra, Consejo Superior de Investigaciones Cientificas, Barcelona, 08003, Spain; Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB T38 6A8, Canada; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, United States; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States; Doctorado en Ciencias mención Ecología y Evolución, Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, 5090000, Chile; Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L7 8TX, United Kingdom; Área de Concervación Guanacaste, Guanacaste, 169-5000, Costa Rica; Department of Anthropology and Primate Molecular Ecology and E...
推荐引用方式 GB/T 7714	Orkin J.D.,Montague M.J.,Tejada-Martinez D.,et al. The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS[J],2021,118(7).
APA	Orkin J.D..,Montague M.J..,Tejada-Martinez D..,de Manuel M..,del Campo J..,...&Melin A.D..(2021).The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Orkin J.D.,et al."The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).