气候变化领域集成服务门户(CCPortal): Hormone seasonality in medical records suggests circannual endocrine circuits

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DOI	10.1073/pnas.2003926118
	Hormone seasonality in medical records suggests circannual endocrine circuits
	Tendler A.; Bar A.; Mendelsohn-Cohen N.; Karin O.; Kohanim Y.K.; Maimon L.; Milo T.; Raz M.; Mayo A.; Tanay A.; Alon U.
发表日期	2021
ISSN	00278424
卷号	118 期号:7
英文摘要	Hormones control the major biological functions of stress response, growth, metabolism, and reproduction. In animals, these hormones show pronounced seasonality, with different set-points for different seasons. In humans, the seasonality of these hormones remains unclear, due to a lack of datasets large enough to discern common patterns and cover all hormones. Here, we analyze an Israeli health record on 46 million person-years, including millions of hormone blood tests. We find clear seasonal patterns: The effector hormones peak in winter−spring, whereas most of their upstream regulating pituitary hormones peak only months later, in summer. This delay of months is unexpected because known delays in the hormone circuits last hours. We explain the precise delays and amplitudes by proposing and testing a mechanism for the circannual clock: The gland masses grow with a timescale of months due to trophic effects of the hormones, generating a feedback circuit with a natural frequency of about a year that can entrain to the seasons. Thus, humans may show coordinated seasonal set-points with a winter−spring peak in the growth, stress, metabolism, and reproduction axes. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Gonadal axis; Growth axis; HPA axis; Systems endocrinology; Thyroid axis
语种	英语
scopus关键词	corticotropin; estradiol; follitropin; growth hormone; hydrocortisone; hypophysis hormone; liothyronine; luteinizing hormone; prolactin; somatomedin C; testosterone; thyrotropin; thyroxine; adult; aged; Article; circadian rhythm; circannual rhythm; controlled study; endocrine function; feedback system; female; growth rate; hormone blood level; hormone response; human; Israeli; male; medical record; metabolism; physiological stress; priority journal; reproduction; seasonal variation; spring; summer; trophic level; winter
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180615
作者单位	Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel; Department of Computer Science, Weizmann Institute of Science, Rehovot, 76100, Israel
推荐引用方式 GB/T 7714	Tendler A.,Bar A.,Mendelsohn-Cohen N.,et al. Hormone seasonality in medical records suggests circannual endocrine circuits[J],2021,118(7).
APA	Tendler A..,Bar A..,Mendelsohn-Cohen N..,Karin O..,Kohanim Y.K..,...&Alon U..(2021).Hormone seasonality in medical records suggests circannual endocrine circuits.Proceedings of the National Academy of Sciences of the United States of America,118(7).
MLA	Tendler A.,et al."Hormone seasonality in medical records suggests circannual endocrine circuits".Proceedings of the National Academy of Sciences of the United States of America 118.7(2021).