气候变化领域集成服务门户(CCPortal): Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

CCPortal

DOI	10.1073/pnas.2014941118
	Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
	Talaia G.; Amick J.; Ferguson S.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:8
英文摘要	PQLC2, a lysosomal cationic amino acid transporter, also serves as a sensor that responds to scarcity of its substrates by recruiting a protein complex composed of C9orf72, SMCR8, and WDR41 to the surface of lysosomes. This protein complex controls multiple aspects of lysosome function. Although it is known that this response to changes in cationic amino acid availability depends on an interaction between PQLC2 and WDR41, the underlying mechanism for the regulated interaction is not known. In this study, we present evidence that the WDR41–PQLC2 interaction is mediated by a short peptide motif in a flexible loop that extends from the WDR41 β-propeller and inserts into a cavity presented by the inward-facing conformation of PQLC2. The data support a transceptor model wherein conformational changes in PQLC2 related to substrate transport regulate the availability of the WDR41-binding site on PQLC2 and mediate recruitment of the WDR41-SMCR8-C9orf72 complex to the surface of lysosomes. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	C9orf72; Lysosome; PQLC2; Transceptor; Transporter
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180571
作者单位	Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, United States; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, United States; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, United States
推荐引用方式 GB/T 7714	Talaia G.,Amick J.,Ferguson S.M.. Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids[J],2021,118(8).
APA	Talaia G.,Amick J.,&Ferguson S.M..(2021).Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.Proceedings of the National Academy of Sciences of the United States of America,118(8).
MLA	Talaia G.,et al."Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids".Proceedings of the National Academy of Sciences of the United States of America 118.8(2021).