气候变化领域集成服务门户(CCPortal): Exhaled aerosol increases with COVID-19 infection, age, and obesity

CCPortal

DOI	10.1073/pnas.2021830118
	Exhaled aerosol increases with COVID-19 infection, age, and obesity
	Edwards D.A.; Ausiello D.; Salzman J.; Devlin T.; Langer R.; Beddingfield B.J.; Fears A.C.; Doyle-Meyers L.A.; Redmann R.K.; Killeen S.Z.; Maness N.J.; Roy C.J.
发表日期	2021
ISSN	00278424
卷号	118 期号:8
英文摘要	COVID-19 transmits by droplets generated from surfaces of airway mucus during processes of respiration within hosts infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. We studied respiratory droplet generation and exhalation in human and nonhuman primate subjects with and without COVID-19 infection to explore whether SARS-CoV-2 infection, and other changes in physiological state, translate into observable evolution of numbers and sizes of exhaled respiratory droplets in healthy and diseased subjects. In our observational cohort study of the exhaled breath particles of 194 healthy human subjects, and in our experimental infection study of eight nonhuman primates infected, by aerosol, with SARS-CoV-2, we found that exhaled aerosol particles vary between subjects by three orders of magnitude, with exhaled respiratory droplet number increasing with degree of COVID-19 infection and elevated BMI-years. We observed that 18% of human subjects (35) accounted for 80% of the exhaled bioaerosol of the group (194), reflecting a superspreader distribution of bioaerosol analogous to a classical 20:80 superspreader of infection distribution. These findings suggest that quantitative assessment and control of exhaled aerosol may be critical to slowing the airborne spread of COVID-19 in the absence of an effective and widely disseminated vaccine. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aerosols; COVID-19; Respiratory medicine; Superspreaders
语种	英语
scopus关键词	aerosol; age; animal; body mass; chemistry; cohort analysis; exhalation; human; isolation and purification; metabolism; mucus; obesity; particle size; pathophysiology; physiology; primate; respiratory system; virology; virus load; Aerosols; Age Factors; Animals; Body Mass Index; Cohort Studies; COVID-19; Exhalation; Humans; Mucus; Obesity; Particle Size; Primates; Respiratory System; SARS-CoV-2; Viral Load
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180533
作者单位	John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States; Sensory Cloud, Boston, MA 02142, United States; Center for Assessment Technology and Continuous Health (CATCH), Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Department of Chemical and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70118, United States; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70118, United States
推荐引用方式 GB/T 7714	Edwards D.A.,Ausiello D.,Salzman J.,et al. Exhaled aerosol increases with COVID-19 infection, age, and obesity[J],2021,118(8).
APA	Edwards D.A..,Ausiello D..,Salzman J..,Devlin T..,Langer R..,...&Roy C.J..(2021).Exhaled aerosol increases with COVID-19 infection, age, and obesity.Proceedings of the National Academy of Sciences of the United States of America,118(8).
MLA	Edwards D.A.,et al."Exhaled aerosol increases with COVID-19 infection, age, and obesity".Proceedings of the National Academy of Sciences of the United States of America 118.8(2021).