气候变化领域集成服务门户(CCPortal): Early systemic immune biomarkers predict bone regeneration after trauma

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DOI	10.1073/pnas.2017889118
	Early systemic immune biomarkers predict bone regeneration after trauma
	Cheng A.; Vantucci C.E.; Krishnan L.; Ruehle M.A.; Kotanchek T.; Wood L.B.; Roy K.; Guldberg R.E.
发表日期	2021
ISSN	00278424
卷号	118 期号:8
英文摘要	Severe traumatic injuries are a widespread and challenging clinical problem, and yet the factors that drive successful healing and restoration of function are still not well understood. One recently identified risk factor for poor healing outcomes is a dysregulated immune response following injury. In a preclinical model of orthopedic trauma, we demonstrate that distinct systemic immune profiles are correlated with impaired bone regeneration. Most notably, elevated blood levels of myeloid-derived suppressor cells (MDSCs) and the immunosuppressive cytokine interleukin-10 (IL-10) are negatively correlated with functional bone regeneration as early as 1 wk posttreatment. Nonlinear multivariate regression also implicated these two factors as the most influential in predictive computational models. These results support a significant relationship between early systemic immune responses to trauma and subsequent local bone regeneration and indicate that elevated circulating levels of MDSCs and IL-10 may be predictive of poor functional healing outcomes and represent novel targets for immunotherapeutic intervention. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bone regeneration; Immune dysregulation; Myeloid-derived suppressor cell; Trauma
语种	英语
scopus关键词	biological marker; interleukin 10; animal experiment; animal model; animal tissue; Article; bone atrophy; bone injury; bone regeneration; circulation; computer model; controlled study; early intervention; female; fracture healing; functional assessment; immune dysregulation; immune response; immunosuppressive treatment; immunotherapy; in vivo study; multivariate logistic regression analysis; myeloid-derived suppressor cell; nonhuman; nonlinear regression analysis; predictive value; priority journal; protein blood level; rat; treatment outcome
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180520
作者单位	George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, United States; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, United States; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, United States; Evolved Analytics LLC, Midland, MI 48640, United States; Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403, United States
推荐引用方式 GB/T 7714	Cheng A.,Vantucci C.E.,Krishnan L.,et al. Early systemic immune biomarkers predict bone regeneration after trauma[J],2021,118(8).
APA	Cheng A..,Vantucci C.E..,Krishnan L..,Ruehle M.A..,Kotanchek T..,...&Guldberg R.E..(2021).Early systemic immune biomarkers predict bone regeneration after trauma.Proceedings of the National Academy of Sciences of the United States of America,118(8).
MLA	Cheng A.,et al."Early systemic immune biomarkers predict bone regeneration after trauma".Proceedings of the National Academy of Sciences of the United States of America 118.8(2021).