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DOI	10.1073/pnas.2022586118
	The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2
	Benton D.J.; Wrobel A.G.; Roustan C.; Borg A.; Xu P.; Martin S.R.; Rosenthal P.B.; Skehel J.J.; Gamblin S.J.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the subsequent structural rearrangements required for viral membrane fusion. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Coronavirus; Cryo-EM; D614G; SARS-CoV-2; Spike
语种	英语
scopus关键词	coronavirus spike glycoprotein; chemistry; cryoelectron microscopy; human; metabolism; physiology; protein conformation; virology; virus entry; COVID-19; Cryoelectron Microscopy; Humans; Protein Conformation; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Virus Internalization
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180509
作者单位	Structural Biology of Disease Processes Laboratory, Francis Crick Institute, London, NW1 1AT, United Kingdom; Structural Biology Science Technology Platform, Francis Crick Institute, London, NW1 1AT, United Kingdom; Precision Medicine Center, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China; Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, London, NW1 1AT, United Kingdom
推荐引用方式 GB/T 7714	Benton D.J.,Wrobel A.G.,Roustan C.,et al. The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2[J],2021,118(9).
APA	Benton D.J..,Wrobel A.G..,Roustan C..,Borg A..,Xu P..,...&Gamblin S.J..(2021).The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Benton D.J.,et al."The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).