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DOI	10.1073/pnas.2018338118
	Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site
	Conti S.; Kaczorowski K.J.; Song G.; Porter K.; Andrabi R.; Burton D.R.; Chakraborty A.K.; Karplus M.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made with little or no success, due, in large part, to the high mutability of the virus. More recent studies showed that a vaccine able to elicit broadly neutralizing antibodies (bnAbs), that is, antibodies that can neutralize a high fraction of global virus variants, has promise to protect against HIV. Such a vaccine has been proposed to involve at least three separate stages: First, activate the appropriate precursor B cells; second, shepherd affinity maturation along pathways toward bnAbs; and, third, polish the Ab response to bind with high affinity to diverse HIV envelopes (Env). This final stage may require immunization with a mixture of Envs. In this paper, we set up a framework based on theory and modeling to design optimal panels of antigens to use in such a mixture. The designed antigens are characterized experimentally and are shown to be stable and to be recognized by known HIV antibodies. © This open access article is distributed under Creative Commons Attribution-NonCommercialNoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Broadly neutralizing antibodies; HIV; Vaccine design
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180505
作者单位	Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, United States; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Scripps Consortium for HIV, AIDS Vaccine Development, The Scripps Research Institute, San Diego, CA 92037, United States; IAVI Neutralizing Antibody Center, The Scripps Research Institute, San Diego, CA 92037, United States; Department of Immunology and Microbiology, The Scripps Research Institute, San Diego, CA 92037, United States; Ragon Institute of Massachusetts, General Hospital, Massachusetts Institute of Technology, Harvard University, Cambridge, MA 02139, United States; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United State...
推荐引用方式 GB/T 7714	Conti S.,Kaczorowski K.J.,Song G.,et al. Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site[J],2021,118(9).
APA	Conti S..,Kaczorowski K.J..,Song G..,Porter K..,Andrabi R..,...&Karplus M..(2021).Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Conti S.,et al."Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).