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DOI	10.1073/pnas.2026309118
	A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
	Zeberg H.; Pääbo S.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	It was recently shown that the major genetic risk factor associated with becoming severely ill with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is inherited from Neandertals. New, larger genetic association studies now allow additional genetic risk factors to be discovered. Using data from the Genetics of Mortality in Critical Care (GenOMICC) consortium, we show that a haplotype at a region on chromosome 12 associated with requiring intensive care when infected with the virus is inherited from Neandertals. This region encodes proteins that activate enzymes that are important during infections with RNA viruses. In contrast to the previously described Neandertal haplotype that increases the risk for severe COVID-19, this Neandertal haplotype is protective against severe disease. It also differs from the risk haplotype in that it has a more moderate effect and occurs at substantial frequencies in all regions of the world outside Africa. Among ancient human genomes in western Eurasia, the frequency of the protective Neandertal haplotype may have increased between 20,000 and 10,000 y ago and again during the past 1,000 y. © This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
英文关键词	COVID-19; Neandertals; OAS1; SARS-CoV-2
语种	英语
scopus关键词	animal; chromosome 12; genetic predisposition; genetics; haplotype; Homo neanderthalensis; human; immunology; molecular evolution; quantitative trait locus; Animals; Chromosomes, Human, Pair 12; COVID-19; Evolution, Molecular; Genetic Predisposition to Disease; Haplotypes; Humans; Neanderthals; Quantitative Trait Loci
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180500
作者单位	Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, D-04103, Germany; Department of Neuroscience, Karolinska Institutet, Stockholm, SE-17177, Sweden; Human Evolutionary Genomics Unit, Okinawa Institute of Science and Technology, Okinawa, 904-0495, Japan
推荐引用方式 GB/T 7714	Zeberg H.,Pääbo S.. A genomic region associated with protection against severe COVID-19 is inherited from Neandertals[J],2021,118(9).
APA	Zeberg H.,&Pääbo S..(2021).A genomic region associated with protection against severe COVID-19 is inherited from Neandertals.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Zeberg H.,et al."A genomic region associated with protection against severe COVID-19 is inherited from Neandertals".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).