气候变化领域集成服务门户(CCPortal): An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization

CCPortal

DOI	10.1073/pnas.2024920118
	An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization
	Pagès S.; Chenouard N.; Chéreau R.; Kouskoff V.; Gambino F.; Holtmaat A.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	The organization of sensory maps in the cerebral cortex depends on experience, which drives homeostatic and long-term synaptic plasticity of cortico-cortical circuits. In the mouse primary somatosensory cortex (S1) afferents from the higher-order, posterior medial thalamic nucleus (POm) gate synaptic plasticity in layer (L) 2/3 pyramidal neurons via disinhibition and the production of dendritic plateau potentials. Here we address whether these thalamocortically mediated responses play a role in whisker map plasticity in S1. We find that trimming all but two whiskers causes a partial fusion of the representations of the two spared whiskers, concomitantly with an increase in the occurrence of POm-driven N-methyl-D-aspartate receptor-dependent plateau potentials. Blocking the plateau potentials restores the archetypical organization of the sensory map. Our results reveal a mechanism for experience-dependent cortical map plasticity in which higher-order thalamocortically mediated plateau potentials facilitate the fusion of normally segregated cortical representations. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Barrel cortex; Dendritic signaling; Posterior medial complex of the thalamus; Somatosensory; Synaptic plasticity
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180494
作者单位	Department of Basic Neurosciences, Center for Neuroscience, Centre Médical Universitaire (CMU), University of Geneva, Geneva, 1211, Switzerland; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, Bordeaux, F-33000, France
推荐引用方式 GB/T 7714	Pagès S.,Chenouard N.,Chéreau R.,et al. An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization[J],2021,118(9).
APA	Pagès S.,Chenouard N.,Chéreau R.,Kouskoff V.,Gambino F.,&Holtmaat A..(2021).An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Pagès S.,et al."An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).