气候变化领域集成服务门户(CCPortal): Regulation of neonatal IgA production by the maternal microbiota

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DOI	10.1073/pnas.2015691118
	Regulation of neonatal IgA production by the maternal microbiota
	Mu Q.; Swartwout B.K.; Edwards M.; Zhu J.; Lee G.; Eden K.; Cabana-Puig X.; McDaniel D.K.; Mao J.; Abdelhamid L.; Brock R.M.; Allen I.C.; Reilly C.M.; Luo X.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	Infants are prone to enteric infections due to an underdeveloped immune system. The maternal microbiota, through shaping the neonatal microbiota, helps establish a strong immune system in infants. We and others have observed the phenomenon of enhanced early neonatal immunoglobulin A (IgA) production in preweaning immunocompetent mice nursed by immunodeficient dams. Here, we show that this enhancement of IgA in neonates results from maternally derived microbiota. In addition, we have found that the neonatal IgA production can be induced by Lactobacillus reuteri, which is enriched in the milk of immunodeficient dams. Moreover, we show that while the production of neonatal IgA is dependent on neonatal T cells, the immunodeficient maternal microbiota-mediated enhancement of neonatal IgA has a T cell-independent component. Indeed, this enhancement may be dependent on type 3 innate lymphoid cells in the neonatal small intestinal lamina propria. Interestingly, maternal microbiota-induced neonatal IgA does not cross-react with common enteric pathogens. Future investigations will determine the functional consequences of having this extra IgA. © This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Lactobacillus reuteri; Maternal microbiota; Neonatal IgA; T cells; Type 3 innate lymphoid cells
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180488
作者单位	Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute, State University, Blacksburg, VA 24061, United States; Translational Biology, Medicine and Health Graduate Program, Virginia Polytechnic Institute, State University, Roanoke, VA 24016, United States; Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, United States; Edward Via College of Osteopathic Medicine, Blacksburg, VA 24060, United States; Department of Medicine, Division of Hematology, Stanford University, School of Medicine, Stanford, CA 94305, United States
推荐引用方式 GB/T 7714	Mu Q.,Swartwout B.K.,Edwards M.,et al. Regulation of neonatal IgA production by the maternal microbiota[J],2021,118(9).
APA	Mu Q..,Swartwout B.K..,Edwards M..,Zhu J..,Lee G..,...&Luo X.M..(2021).Regulation of neonatal IgA production by the maternal microbiota.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	Mu Q.,et al."Regulation of neonatal IgA production by the maternal microbiota".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).