气候变化领域集成服务门户(CCPortal): Linker domain function predicts pathogenic MLH1 missense variants

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DOI	10.1073/pnas.2019215118
	Linker domain function predicts pathogenic MLH1 missense variants
	London J.; Martín-López J.; Yang I.; Liu J.; Lee J.-B.; Fishel R.
发表日期	2021
ISSN	00278424
卷号	118 期号:9
英文摘要	The pathogenic consequences of 369 unique human HsMLH1 missense variants has been hampered by the lack of a detailed function in mismatch repair (MMR). Here single-molecule images show that HsMSH2-HsMSH6 provides a platform for HsMLH1-HsPMS2 to form a stable sliding clamp on mismatched DNA. The mechanics of sliding clamp progression solves a significant operational puzzle in MMR and provides explicit predictions for the distribution of clinically relevant HsMLH1 missense mutations. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	HNPCC; Lynch syndrome; Mismatch repair; Single molecule; Sliding clamp
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180465
作者单位	Department of Cancer Biology and Genetics, Ohio State University, Wexner Medical Center, Columbus, OH 43210, United States; Department of Physics, Pohang University of Science and Technology, Pohang, 37673, South Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, South Korea
推荐引用方式 GB/T 7714	London J.,Martín-López J.,Yang I.,et al. Linker domain function predicts pathogenic MLH1 missense variants[J],2021,118(9).
APA	London J.,Martín-López J.,Yang I.,Liu J.,Lee J.-B.,&Fishel R..(2021).Linker domain function predicts pathogenic MLH1 missense variants.Proceedings of the National Academy of Sciences of the United States of America,118(9).
MLA	London J.,et al."Linker domain function predicts pathogenic MLH1 missense variants".Proceedings of the National Academy of Sciences of the United States of America 118.9(2021).