气候变化领域集成服务门户(CCPortal): Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation

CCPortal

DOI	10.1073/pnas.2015685118
	Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation
	Liu X.; Qiao Z.; Chai Y.; Zhu Z.; Wu K.; Ji W.; Li D.; Xiao Y.; Mao L.; Chang C.; Wen Q.; Song B.; Shu Y.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Various neuromodulation approaches have been employed to alter neuronal spiking activity and thus regulate brain functions and alleviate neurological disorders. Infrared neural stimulation (INS) could be a potential approach for neuromodulation because it requires no tissue contact and possesses a high spatial resolution. However, the risk of overheating and an unclear mechanism hamper its application. Here we show that midinfrared stimulation (MIRS) with a specific wavelength exerts nonthermal, long-distance, and reversible modulatory effects on ion channel activity, neuronal signaling, and sensorimotor behavior. Patch-clamp recording from mouse neocortical pyramidal cells revealed that MIRS readily provides gain control over spiking activities, inhibiting spiking responses to weak inputs but enhancing those to strong inputs. MIRS also shortens action potential (AP) waveforms by accelerating its repolarization, through an increase in voltage-gated K+ (but not Na+) currents. Molecular dynamics simulations further revealed that MIRS-induced resonance vibration of –C=O bonds at the K+ channel ion selectivity filter contributes to the K+ current increase. Importantly, these effects are readily reversible and independent of temperature increase. At the behavioral level in larval zebrafish, MIRS modulates startle responses by sharply increasing the slope of the sensorimotor input–output curve. Therefore, MIRS represents a promising neuromodulation approach suitable for clinical application. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Action potential; Excitability; Infrared light; Neuromodulation; Potassium channel
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180385
作者单位	State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China; Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, 710049, China; Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing, 100071, China; Hefei National Laboratory for Physical Sciences, Microscale Center for Integrative Imaging, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China; Key Laboratory of Brain Function and Disease, Chinese Academy of Sciences, Hefei, 230027, China; School of Optical-Electrical Computer Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry...
推荐引用方式 GB/T 7714	Liu X.,Qiao Z.,Chai Y.,et al. Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation[J],2021,118(10).
APA	Liu X..,Qiao Z..,Chai Y..,Zhu Z..,Wu K..,...&Shu Y..(2021).Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Liu X.,et al."Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).