气候变化领域集成服务门户(CCPortal): Local induction of bladder Th1 responses to combat urinary tract infections

CCPortal

DOI	10.1073/pnas.2026461118
	Local induction of bladder Th1 responses to combat urinary tract infections
	Wu J.; Bao C.; Lee Reinhardt R.; Abraham S.N.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Given the high frequency of urinary tract infections (UTIs) and their recurrence, there is keen interest in developing effective UTI vaccines. Currently, most vaccine studies, including those in humans, involve parenteral vaccination aimed at evoking and sustaining elevated levels of systemic antibody directed at the uropathogens. In view of recent reports of aberrant Th2-biased bladder immune responses to infection, we hypothesized that immunizing mice intravesically with antigens from uropathogenic Escherichia coli (UPEC) combined with a Th1-skewing adjuvant could correct this defect and promote protection against UTIs. Here we report that compared with mice immunized subcutaneously with this vaccine combination, intravesically immunized mice were markedly more protected from UTIs because of their distinctive ability to recruit Th1 cells into the bladder. This mode of vaccination was effective even in mice that experienced multiple UTIs and displayed pronounced aberrant bladder immune responses. Thus, intravesical vaccination with one or more UPEC antigens to induce bladder Th1 responses represents a superior strategy to combat UTIs, especially in UTI-prone subjects. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bladder; Th1; UTI; Vaccine
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180378
作者单位	Department of Immunology, Duke University Medical Center, Durham, NC 27710, United States; Department of Pathology, Duke University Medical Center, Durham, NC 27710, United States; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, United States; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States; Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, United States; Program in Emerging Infectious Diseases, Duke–National University of Singapore, Singapore, 169857, Singapore
推荐引用方式 GB/T 7714	Wu J.,Bao C.,Lee Reinhardt R.,et al. Local induction of bladder Th1 responses to combat urinary tract infections[J],2021,118(10).
APA	Wu J.,Bao C.,Lee Reinhardt R.,&Abraham S.N..(2021).Local induction of bladder Th1 responses to combat urinary tract infections.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Wu J.,et al."Local induction of bladder Th1 responses to combat urinary tract infections".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).