气候变化领域集成服务门户(CCPortal): TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer

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DOI	10.1073/pnas.2017089118
	TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer
	Wolfsberger J.; Sakil H.A.M.; Zhou L.; Van Bree N.; Baldisseri E.; De Souza Ferreira S.; Zubillaga V.; Stantic M.; Fritz N.; Hartman J.; Rolny C.; Wilhelm M.T.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Infiltration of tumor-promoting immune cells is a strong driver of tumor progression. Especially the accumulation of macrophages in the tumor microenvironment is known to facilitate tumor growth and to correlate with poor prognosis in many tumor types. TAp73, a member of the p53/p63/p73 family, acts as a tumor suppressor and has been shown to suppress tumor angiogenesis. However, what role TAp73 has in regulating immune cell infiltration is unknown. Here, we report that low levels of TAp73 correlate with an increased NF-κB–regulated inflammatory signature in breast cancer. Furthermore, we show that loss of TAp73 results in NF-κB hyperactivation and secretion of Ccl2, a known NF-κB target and chemoattractant for monocytes and macrophages. Importantly, TAp73-deficient tumors display an increased accumulation of protumoral macrophages that express the mannose receptor (CD206) and scavenger receptor A (CD204) compared to controls. The relevance of TAp73 expression in human breast carcinoma was further accentuated by revealing that TAp73 expression correlates negatively with the accumulation of protumoral CD163+ macrophages in breast cancer patient samples. Taken together, our findings suggest that TAp73 regulates macrophage accumulation and phenotype in breast cancer through inhibition of the NF-κB pathway. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Breast cancer; NF-κB; P73; Tumor-associated macrophages
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180375
作者单位	Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 171 65, Sweden; Science for Life Laboratory, Department of Oncology–Pathology, Karolinska Institutet, Stockholm, 171 65, Sweden; Department of Oncology–Pathology, Karolinska Institutet, Stockholm, 171 64, Sweden
推荐引用方式 GB/T 7714	Wolfsberger J.,Sakil H.A.M.,Zhou L.,等. TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer[J],2021,118(10).
APA	Wolfsberger J..,Sakil H.A.M..,Zhou L..,Van Bree N..,Baldisseri E..,...&Wilhelm M.T..(2021).TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Wolfsberger J.,et al."TAp73 represses NF-κB–mediated recruitment of tumor-associated macrophages in breast cancer".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).