气候变化领域集成服务门户(CCPortal): Progenitor cell diversity in the developing mouse neocortex

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DOI	10.1073/pnas.2018866118
	Progenitor cell diversity in the developing mouse neocortex
	Ruan X.; Kang B.; Qi C.; Lin W.; Wang J.; Zhang X.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	In the mammalian neocortex, projection neuron types are sequentially generated by the same pool of neural progenitors. How neuron type specification is related to developmental timing remains unclear. To determine whether temporal gene expression in neural progenitors correlates with neuron type specification, we performed single-cell RNA sequencing (scRNA-Seq) analysis of the developing mouse neocortex. We uncovered neuroepithelial cell enriched genes such as Hmga2 and Ccnd1 when compared to radial glial cells (RGCs). RGCs display dynamic gene expression over time; for instance, early RGCs express higher levels of Hes5, and late RGCs show higher expression of Pou3f2. Interestingly, intermediate progenitor cell marker gene Eomes coexpresses temporally with known neuronal identity genes at different developmental stages, though mostly in postmitotic cells. Our results delineate neural progenitor cell diversity in the developing mouse neocortex and support that neuronal identity genes are transcriptionally evident in Eomes-positive cells. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cell identity; Developmental timing; Neural progenitor; Neuronal diversity; ScRNA-Seq
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180364
作者单位	Department of Human Genetics, The University of Chicago, Chicago, IL 60637, United States; Department of Statistics, The University of Chicago, Chicago, IL 60637, United States; The Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL 60637, United States
推荐引用方式 GB/T 7714	Ruan X.,Kang B.,Qi C.,et al. Progenitor cell diversity in the developing mouse neocortex[J],2021,118(10).
APA	Ruan X.,Kang B.,Qi C.,Lin W.,Wang J.,&Zhang X..(2021).Progenitor cell diversity in the developing mouse neocortex.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Ruan X.,et al."Progenitor cell diversity in the developing mouse neocortex".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).