气候变化领域集成服务门户(CCPortal): Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations

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DOI	10.1073/pnas.2016653118
	Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations
	Chen Q.; Chen J.; Li Y.; Liu D.; Zeng Y.; Tian Z.; Yunus A.; Yang Y.; Lu J.; Song X.; Yuan Y.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Osteosarcoma is the most common malignant tumor of bone predominately affecting adolescents and young adults. Based on animal studies, a viral etiology of osteosarcoma was proposed more than a half-century ago, but no viral association with human osteosarcoma has been found. The Uyghur ethnic population in Xinjiang, China, has an unusually high prevalence of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and elevated incidence of osteosarcoma. In the current study, we explored the possible association of KSHV infection and osteosarcoma occurrence. Our seroepidemiological study revealed that KSHV prevalence was significantly elevated in Uyghur osteosarcoma patients versus the general Uyghur population (OR, 10.23; 95%CI, 4.25, 18.89). The KSHV DNA genome and viral latent nuclear antigen LANA were detected in most osteosarcoma tumor cells. Gene expression profiling analysis showed that KSHV-positive osteosarcoma represents a distinct subtype of osteosarcomas with viral gene-activated signaling pathways important for osteosarcoma development. We conclude that KSHV infection is a risk factor for osteosarcoma, and KSHV is associated with some osteosarcomas, representing a newly identified viral-associated endemic cancer. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Human herpesvirus type 8; Kaposi’s sarcoma-associated herpesvirus; Osteosarcoma; Seroepidemiology; Viral-associated endemic cancer
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180346
作者单位	Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China; First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region, 830011, China; Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China; Shihezi University, Shihezi, Xinjiang Uyghur Autonomous Region, 832000, China; Department of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, United States
推荐引用方式 GB/T 7714	Chen Q.,Chen J.,Li Y.,等. Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations[J],2021,118(10).
APA	Chen Q..,Chen J..,Li Y..,Liu D..,Zeng Y..,...&Yuan Y..(2021).Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Chen Q.,et al."Kaposi’s sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).