气候变化领域集成服务门户(CCPortal): Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain

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DOI	10.1073/pnas.2019826118
	Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain
	Barber A.F.; Fong S.Y.; Kolesnik A.; Fetchko M.; Sehgal A.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions, but the mechanism by which clock cells regulate downstream targets is not known. We show here that the pars intercerebralis (PI), previously identified as a target of the morning cells in the clock network, also receives input from evening cells. We determined that morning and evening clock neurons have time-of-day–dependent connectivity to the PI, which is regulated by specific peptides as well as by fast neurotransmitters. Interestingly, PI cells that secrete the peptide DH44, and control rest:activity rhythms, are inhibited by clock inputs while insulin-producing cells (IPCs) are activated, indicating that the same clock cells can use different mechanisms to drive cycling in output neurons. Inputs of morning cells to IPCs are relevant for the circadian rhythm of feeding, reinforcing the role of the PI as a circadian relay that controls multiple behavioral outputs. Our findings provide mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Circadian rhythm; Drosophila; Feeding; Molecular clock
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180342
作者单位	Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, United States
推荐引用方式 GB/T 7714	Barber A.F.,Fong S.Y.,Kolesnik A.,et al. Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain[J],2021,118(10).
APA	Barber A.F.,Fong S.Y.,Kolesnik A.,Fetchko M.,&Sehgal A..(2021).Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Barber A.F.,et al."Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).