气候变化领域集成服务门户(CCPortal): Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains

CCPortal

DOI	10.1073/pnas.2007724118
	Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains
	Kreeger L.J.; Connelly C.J.; Mehta P.; Zemelman B.V.; Golding N.L.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	The central nucleus of the inferior colliculus (ICC) integrates information about different features of sound and then distributes this information to thalamocortical circuits. However, the lack of clear definitions of circuit elements in the ICC has limited our understanding of the nature of these circuit transformations. Here, we combine virus-based genetic access with electrophysiological and optogenetic approaches to identify a large family of excitatory, cholecystokinin-expressing thalamic projection neurons in the ICC of the Mongolian gerbil. We show that these neurons form a distinct cell type, displaying uniform morphology and intrinsic firing features, and provide powerful, spatially restricted excitation exclusively to the ventral auditory thalamus. In vivo, these neurons consistently exhibit V-shaped receptive field properties but strikingly diverse temporal responses to sound. Our results indicate that temporal response diversity is maintained within this population of otherwise uniform cells in the ICC and then relayed to cortex through spatially restricted thalamic subdomains. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	AAV; Cholecystokinin; Driver synapses; Inferior colliculus; Medial geniculate
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180325
作者单位	Department of Neuroscience, Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712-0248, United States
推荐引用方式 GB/T 7714	Kreeger L.J.,Connelly C.J.,Mehta P.,et al. Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains[J],2021,118(10).
APA	Kreeger L.J.,Connelly C.J.,Mehta P.,Zemelman B.V.,&Golding N.L..(2021).Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Kreeger L.J.,et al."Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).