气候变化领域集成服务门户(CCPortal): A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa

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DOI	10.1073/pnas.2019346118
	A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa
	Chauvigné F.; Ducat C.; Ferré A.; Hansen T.; Carrascal M.; Abián J.; Finn R.N.; Cerdà J.
发表日期	2021
ISSN	00278424
卷号	118 期号:10
英文摘要	The primary task of a spermatozoon is to deliver its nuclear payload to the egg to form the next-generation zygote. With polyandry repeatedly evolving in the animal kingdom, however, sperm competition has become widespread, with the highest known intensities occurring in fish. Yet, the molecular controls regulating spermatozoon swimming performance in these organisms are largely unknown. Here, we show that the kinematic properties of postactivated piscine spermatozoa are regulated through a conserved trafficking mechanism whereby a peroxiporin ortholog of mammalian aquaporin-8 (Aqp8bb) is inserted into the inner mitochondrial membrane to facilitate H2O2 efflux in order to maintain ATP production. In teleosts from more ancestral lineages, such as the zebrafish (Danio rerio) and the Atlantic salmon (Salmo salar), in which spermatozoa are activated in freshwater, an intracellular Ca2+-signaling directly regulates this mechanism through monophosphorylation of the Aqp8bb N terminus. In contrast, in more recently evolved marine teleosts, such the gilthead seabream (Sparus aurata), in which spermatozoa activation occurs in seawater, a cross-talk between Ca2+- and oxidative stress-activated pathways generate a multiplier regulation of channel trafficking via dual N-terminal phosphorylation. These findings reveal that teleost spermatozoa evolved increasingly sophisticated detoxification pathways to maintain swimming performance under a high osmotic stress, and provide insight into molecular traits that are advantageous for postcopulatory sexual selection. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aquaporin; Mitochondria; Oxidative stress; Sexual selection; Sperm
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180315
作者单位	Institute of Agrifood Research and Technology, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, 08193, Spain; Institute of Marine Research, Matre Aquaculture Research Station, Matredal, 5984, Norway; Consejo Superior de Investigaciones Cientificas, Universitat Autònoma de Barcelona, Proteomics Laboratory, Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Cientificas-August Pi i Sunyer Biomedical Research Institute, Barcelona, 08193, Spain; Department of Biology, Bergen High Technology Centre, University of Bergen, Bergen, 5020, Norway
推荐引用方式 GB/T 7714	Chauvigné F.,Ducat C.,Ferré A.,et al. A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa[J],2021,118(10).
APA	Chauvigné F..,Ducat C..,Ferré A..,Hansen T..,Carrascal M..,...&Cerdà J..(2021).A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa.Proceedings of the National Academy of Sciences of the United States of America,118(10).
MLA	Chauvigné F.,et al."A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa".Proceedings of the National Academy of Sciences of the United States of America 118.10(2021).