气候变化领域集成服务门户(CCPortal): Interventions can shift the thermal optimum for parasitic disease transmission

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DOI	10.1073/pnas.2017537118
	Interventions can shift the thermal optimum for parasitic disease transmission
	Nguyen K.H.; Boersch-Supan P.H.; Hartman R.B.; Mendiola S.Y.; Harwood V.J.; Civitello D.J.; Rohr J.R.
发表日期	2021
ISSN	00278424
卷号	118 期号:11
英文摘要	Temperature constrains the transmission of many pathogens. Interventions that target temperature-sensitive life stages, such as vector controlmeasures that kill intermediate hosts, could shift the thermal optimum of transmission, thereby altering seasonal disease dynamics and rendering interventions less effective at certain times of the year and with global climate change. To test these hypotheses, we integrated an epidemiological model of schistosomiasis with empirically determined temperature-dependent traits of the human parasite Schistosoma mansoni and its intermediate snail host (Biomphalaria spp.). We show that transmission risk peaks at 21.7 °C (Topt), and simulated interventions targeting snails and free-living parasite larvae increased Toptby up to 1.3 °C because interventionrelated mortality overrode thermal constraints on transmission. This Toptshift suggests that snail control is more effective at lower temperatures, and global climate change will increase schistosomiasis risk in regions that move closer to Topt. Considering regional transmission phenologies and timing of interventions when local conditions approach Toptwill maximize human health outcomes. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Climate change; Epidemiological modeling; Neglected tropical disease; Snail control; Temperature
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180297
作者单位	Department of Biology, Emory University, Atlanta, GA 30322, United States; British Trust for Ornithology, Thetford, IP24 2PU, United Kingdom; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, United States; Department of Geography, University of Florida, Gainesville, FL 32611, United States; Department of Integrative Biology, University of South Florida, Tampa, FL 33620, United States; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, United States; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, United States; Environmental Change Initiative, University of Notre Dame, Notre Dame, IN 46556, United States
推荐引用方式 GB/T 7714	Nguyen K.H.,Boersch-Supan P.H.,Hartman R.B.,et al. Interventions can shift the thermal optimum for parasitic disease transmission[J],2021,118(11).
APA	Nguyen K.H..,Boersch-Supan P.H..,Hartman R.B..,Mendiola S.Y..,Harwood V.J..,...&Rohr J.R..(2021).Interventions can shift the thermal optimum for parasitic disease transmission.Proceedings of the National Academy of Sciences of the United States of America,118(11).
MLA	Nguyen K.H.,et al."Interventions can shift the thermal optimum for parasitic disease transmission".Proceedings of the National Academy of Sciences of the United States of America 118.11(2021).